(R)-(+)-2-METHOXYPROPIONIC ACID

Base Information

• Chemical Name: (R)-(+)-2-METHOXYPROPIONIC ACID
• CAS No.: 23943-96-6
• Molecular Formula: C4H8 O3
• Molecular Weight: 104.106
• Hs Code.: 2918990090
• DSSTox Substance ID: DTXSID10946768
• Mol file: 23943-96-6.mol

Synonyms:Propanoicacid, 2-methoxy-, (R)-; Propionic acid, 2-methoxy-, (R)-(+)- (8CI);(R)-(+)-2-Methoxypropanoic acid; (R)-(+)-2-Methoxypropionic acid;(R)-2-Methoxypropanoic acid

Chemical Property of (R)-(+)-2-METHOXYPROPIONIC ACID

Chemical Property:

• Vapor Pressure: 0.144mmHg at 25°C
• Refractive Index: 1.4132-1.4152
• Boiling Point: 199.4°Cat760mmHg
• PKA: 3.59±0.10(Predicted)
• Flash Point: 87.1°C
• PSA: 46.53000
• Density: 1.085g/cm³
• LogP: 0.10590
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 103.039519081
• Heavy Atom Count: 7
• Complexity: 63.8

Purity/Quality:

98%,99%, ^*data from raw suppliers

(R)-(+)-2-MethoxypropionicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38-41
• Safety Statements: 37/39-26-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C(=O)[O-])OC
• Isomeric SMILES: C[C@H](C(=O)[O-])OC
• Uses: (R)-(+)-2-Methoxypropionic Acid (cas# 23943-96-6) is a compound useful in organic synthesis.

Technology Process of (R)-(+)-2-METHOXYPROPIONIC ACID

There total 8 articles about (R)-(+)-2-METHOXYPROPIONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

methyl (2R)-2-methoxypropanoate (54656-63-2,92935-45-0) → (R)-(+)-2-methoxypropionic acid (23943-96-6)

Guidance literature:

With methanol; s-hydrindacene; water; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1002/anie.202111549

Reference yield:

(R)-2-Methoxy-propionic acid 4-nitro-phenyl ester (139265-30-8) → 4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + (R)-(+)-2-methoxypropionic acid (23943-96-6)

Guidance literature:

With Tris-HCl buffer; N,N-dimethyl-formamide; calcium chloride; at 25 ℃; Rate constant; Equilibrium constant; with chymotrypsin, pH 8; dissociation constant of enzyme-substrate complex K_S; k(S/R);

DOI:10.1248/cpb.39.2748

Reference yield:

methyl lactate (547-64-8,2155-30-8) + methyl iodide (74-88-4) → (R)-(+)-2-methoxypropionic acid (23943-96-6)

Guidance literature:

With silver tetrafluoroborate; In water;

upstream raw materials:

methyl (2R)-2-methoxypropanoate

sodium methylate

2-Bromopropionic acid

(R)-2-Methoxy-propionic acid 4-nitro-phenyl ester

Downstream raw materials:

(R)-2-Methoxy-propionic acid 4-nitro-phenyl ester

(R)-N-(4-((4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)methyl)pyridin-2-yl)-2-methoxypropanamide

Refernces

• 1、 Pelto, Ryan B.,Pratt. "Serendipitous discovery of α-hydroxyalkyl esters as β-lactamase substrates". experimental part. p. 10496 - 10506. Retrieved 2011/10/18.
• 2、 -. "Piperidine derivatives, compositions and use". . . Retrieved 2008/06/13.