4-Chloro-isatoic anhydride

Base Information

• Chemical Name: 4-Chloro-isatoic anhydride
• CAS No.: 40928-13-0
• Molecular Formula: C8H4ClNO3
• Molecular Weight: 197.578
• Hs Code.: 2934999090
• Mol file: 40928-13-0.mol

Synonyms:Isatoicanhydride, 4-chloro- (6CI);NSC310230;4-Chloroisatoic anhydride;7-Chloro-2H-3,1-benzoxazine-2,4(1H)-dione;7-Chloroisatoic anhydride;

Chemical Property of 4-Chloro-isatoic anhydride

Chemical Property:

• Appearance/Colour: White solide
• Melting Point: 255-259 °C
• Refractive Index: 1.6
• PKA: 9.95±0.20(Predicted)
• PSA: 63.07000
• Density: 1.54 g/cm³
• LogP: 1.13470
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: soluble in Dimethylformamide

Purity/Quality:

99% ^*data from raw suppliers

4-Chloroisatoic Anhydride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 4-Chloro-isatoic anhydride

There total 1 articles about 4-Chloro-isatoic anhydride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

phosgene (75-44-5) + sodium carbonate (497-19-8) + 2-Amino-4-chlorobenzoic acid (89-77-0) → 4-chloroisatoic anhydride (40928-13-0) + 2-amino-4-chloro-5-nitrobenzamide (252232-80-7)

Guidance literature:

In water; toluene;

Reference yield: 91.0%

4-chloroisatoic anhydride (40928-13-0) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → 4-chloroanthranilic acid N-methoxy-N-methylamide (214971-18-3)

Guidance literature:

N,O-dimethylhydroxylamine*hydrochloride; With triethylamine; In ethanol; water; at 20 ℃; for 0.166667h;

4-chloroisatoic anhydride; In ethanol; water; for 3h; Heating;

DOI:10.1021/jm051185t

Reference yield: 90.0%

4-chloroisatoic anhydride (40928-13-0) + p-toluidine (106-49-0,12221-03-3) + o-carboxybenzaldehyde (119-67-5) → 2-chloro-6-(p-tolyl)-6,6a-dihydroisoindolo[2,1-a]quinazoline-5,11-dione

Guidance literature:

With C₁₄H₁₃O₅PolS; In water; at 100 ℃; for 8h; Green chemistry;

DOI:10.1016/j.molstruc.2021.131922

upstream raw materials:

phosgene

sodium carbonate

2-Amino-4-chlorobenzoic acid

Downstream raw materials:

6-chloro-2,3-dihydro-isoxazolo[3,2-b]quinazolin-9-one

2-amino-4-chloro-N-phenylbenzamide

2-Amino-4-chloro-N-(4-methyl-piperazin-1-yl)-benzamide

6-chloro-3-(2,4-dichlorophenyl)-3,4-dihydro-1,9(2H,10H)-acridinedione

Refernces