ethyl 4-amino-3-iodobenzoate

Base Information

• Chemical Name: ethyl 4-amino-3-iodobenzoate
• CAS No.: 62875-84-7
• Molecular Formula: C9H10INO2
• Molecular Weight: 291.088
• Mol file: 62875-84-7.mol

Synonyms:4-Amino-3-iodobenzoic acid, ethyl ester;

Chemical Property of ethyl 4-amino-3-iodobenzoate

Chemical Property:

• Melting Point: 82.6-83.0 °C
• Boiling Point: 378.8 °C at 760 mmHg
• PKA: 0.44±0.10(Predicted)
• Flash Point: 182.9 °C
• PSA: 52.32000
• Density: 1.73 g/cm³
• LogP: 2.63130

Purity/Quality:

99% ^*data from raw suppliers

Ethyl4-Amino-3-iodobenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 4-amino-3-iodobenzoate

There total 5 articles about ethyl 4-amino-3-iodobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

p-aminoethylbenzoate (94-09-7) → 3-iodobenzocaine (62875-84-7)

Guidance literature:

With N,N,N-trimethylbenzenemethanaminium dichloroiodate; calcium carbonate; In methanol; dichloromethane; for 48h;

DOI:10.1021/jm00090a013

Reference yield:

benzyltrimethylammonium dichloroiodate + p-aminoethylbenzoate (94-09-7) → 3-iodobenzocaine (62875-84-7)

Guidance literature:

With calcium carbonate; In methanol; diethyl ether; dichloromethane;

Reference yield:

p-aminoethylbenzoate (94-09-7) → 3-iodobenzocaine (62875-84-7)

Guidance literature:

With iodine; sodium hydrogencarbonate; In dichloromethane; water; at 0 - 20 ℃; for 72h;

upstream raw materials:

ethanol

4-amino-3-iodobenzoic acid

p-aminoethylbenzoate

4-amino-benzoic acid

Downstream raw materials:

4-amino-3-iodobenzoic acid

Refernces

• 1、 Kumar, Vikash,Munkhbat, Oyuntuya,Secinti, Hatice,Thayumanavan. "Disassembly of polymeric nanoparticles with enzyme-triggered polymer unzipping: Polyelectrolyte complexes: Vs. amphiphilic nanoassemblies". supporting information. p. 8456 - 8459. Retrieved 2020/08/13.
• 2、 Ikeda,Omote,Kusumoto,Komori,Tarui,Sato,Ando. "A dramatic enhancing effect of InBr3 towards the oxidative Sonogashira cross-coupling reaction of 2-ethynylanilines". supporting information. p. 2127 - 2133. Retrieved 2016/02/18.