2-(2-(2-Methoxyethoxy)ethoxy)ethyl 4-Methylbenzenesulfonate

Base Information

• Chemical Name: 2-(2-(2-Methoxyethoxy)ethoxy)ethyl 4-Methylbenzenesulfonate
• CAS No.: 62921-74-8
• Molecular Formula: C14H22O6S
• Molecular Weight: 318.391
• Mol file: 62921-74-8.mol

Synonyms:3,6,9-trioxadecyl tosylate;CH3(OCH2CH2)3OTs;Ethanol,2-[2-(2-methoxyethoxy)ethoxy]-,4-methylbenzenesulfonate;CH3OC2H4OC2H4OC2H4OTs;2-[2-(2-Methoxyethoxy)ethoxy]ethyl 4-methylbenzenesulfonate;triethyleneglycol monotosylate;triethylene glycol methyl tosyl ether;triethyleneglycol monomethyl ether tosylate;

Chemical Property of 2-(2-(2-Methoxyethoxy)ethoxy)ethyl 4-Methylbenzenesulfonate

Chemical Property:

• Refractive Index: 1.53
• Boiling Point: 432.3±35.0 °C(Predicted)
• PSA: 110.67000
• Density: 1.170±0.06 g/cm3(Predicted)
• LogP: 1.98080

Purity/Quality:

99% ^*data from raw suppliers

2-[2-(2-Methoxyethoxy)ethoxy]ethyl 4-Methylbenzenesulfonate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: m-PEG4-Tos is a PEG linker containing a tosyl group. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media.

Technology Process of 2-(2-(2-Methoxyethoxy)ethoxy)ethyl 4-Methylbenzenesulfonate

There total 12 articles about 2-(2-(2-Methoxyethoxy)ethoxy)ethyl 4-Methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

triethylene glucol monomethyl ether (112-35-6,95507-80-5) + p-toluenesulfonyl chloride (98-59-9) → 2-(2-(2-methoxyethoxy)ethoxy)ethyl p-toluenesulfonate (62921-74-8,518012-62-9,58320-73-3)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1021/ja073962f

Reference yield: 99.0%

triethylene glucol monomethyl ether (112-35-6,95507-80-5) + toluene-4-sulfonic acid (104-15-4) → 2-(2-(2-methoxyethoxy)ethoxy)ethyl p-toluenesulfonate (62921-74-8,518012-62-9,58320-73-3)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; at 0 ℃; for 3h;

DOI:10.1080/10610278.2015.1092535

Reference yield: 99.0%

2-methoxy-ethanol (109-86-4,95507-80-5) → 2-(2-(2-methoxyethoxy)ethoxy)ethyl p-toluenesulfonate (62921-74-8,518012-62-9,58320-73-3)

Guidance literature:

With potassium penicillin V; In tetrahydrofuran; water;

upstream raw materials:

triethylene glucol monomethyl ether

p-toluenesulfonyl chloride

triethylene glycol monobenzyl ether

triethylene glycol benzyl methyl ether

Downstream raw materials:

1,5-bis(2'-(1,4,7,10-tetraoxaundecanyl)phenyl)-1,4-pentadien-3-one

(3,5-bis-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-phenyl)-methanol

1,4-diiodo-2,5-bis{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}benzene

5-{2-[2-(2-methoxy)ethoxy]ethoxy}benzene-1,3-dicarboxylic acid dimethyl ester

Refernces

• 1、 -. "FLUORINATED AMINE OXIDE SURFACTANTS". . . Retrieved 2022/02/27.
• 2、 -. "NERVE-SPECIFIC FLUOROPHORE FORMULATIONS FOR DIRECT AND SYSTEMIC ADMINISTRATION". Page/Page column 37-38. . Retrieved 2021/08/13.