1-(2-Thienyl)ethanone phenylhydrazone

Base Information

• Chemical Name: 1-(2-Thienyl)ethanone phenylhydrazone
• CAS No.: 55968-17-7
• Molecular Formula: C12H12N2S
• Molecular Weight: 216.307
• Hs Code.: 2934999090
• European Community (EC) Number: 663-996-1
• NSC Number: 146220
• Nikkaji Number: J90.302G
• Mol file: 55968-17-7.mol

Synonyms:55968-17-7;NSC146220;1-(2-Thienyl)ethanone phenylhydrazone;NSC-146220

Chemical Property of 1-(2-Thienyl)ethanone phenylhydrazone

Chemical Property:

• Vapor Pressure: 0.000107mmHg at 25°C
• Melting Point: 94 °C
• Boiling Point: 337.1°Cat760mmHg
• PKA: 16.37±0.10(Predicted)
• Flash Point: 157.7°C
• PSA: 52.63000
• Density: 1.12g/cm³
• LogP: 3.65720
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 216.07211956
• Heavy Atom Count: 15
• Complexity: 222

Purity/Quality:

99% ^*data from raw suppliers

1-(2-THIENYL)ETHANONE PHENYLHYDRAZONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(=NNC1=CC=CC=C1)C2=CC=CS2
• Isomeric SMILES: C/C(=N/NC1=CC=CC=C1)/C2=CC=CS2

Technology Process of 1-(2-Thienyl)ethanone phenylhydrazone

There total 5 articles about 1-(2-Thienyl)ethanone phenylhydrazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-Acetylthiophene (88-15-3,97511-16-5) + phenylhydrazine hydrochloride (59-88-1) → 1-[1-(thiophen-2-yl)ethylidene]-2-phenylhydrazine (55968-17-7)

Guidance literature:

With sodium acetate; In ethanol; at 80 ℃; for 0.0833333h; Microwave irradiation; air-cooling;

DOI:10.1021/co100015b

Reference yield: 88.0%

2-[1-(thiophen-2-yl)ethylidene]malononitrile (10432-44-7) + phenylhydrazine (100-63-0) → 1-[1-(thiophen-2-yl)ethylidene]-2-phenylhydrazine (55968-17-7)

Guidance literature:

In ethanol; for 2h; Heating;

DOI:10.1080/10426509808545453

Reference yield: 81.0%

2-Acetylthiophene (88-15-3,97511-16-5) + phenylhydrazine (100-63-0) → 1-[1-(thiophen-2-yl)ethylidene]-2-phenylhydrazine (55968-17-7)

Guidance literature:

In ethanol; for 5h; Reflux;

DOI:10.1016/j.ejmech.2009.03.026

upstream raw materials:

2-[1-(thiophen-2-yl)ethylidene]malononitrile

phenylhydrazine

phenylhydrazine hydrochloride

2-Acetylthiophene

Downstream raw materials:

1-phenyl-3-thiophen-2-yl-1H-pyrazole-4-carboxylic acid

N-((2-(thiophen-2-yl)-1H-indol-3-yl)(m-tolyl)methyl)toluenesulfonamide

N-((4-bromophenyl)(2-(thiophen-2-yl)-1H-indol-3-yl)methyl)toluenesulfonamide

Refernces

• 1、 Liang, Qianqian,Liu, Hong-Min,Ma, Li-Ying,Ren, Hongmei,Wu, Yang,Zhang, Kun,Zhang, Xinhui,Zhao, Bing,Zheng, Yi-Chao. "Discovery of pyrazole derivatives as cellular active inhibitors of histone lysine specific demethylase 5B (KDM5B/JARID1B)". . . Retrieved 2020/03/10.
• 2、 Sundergoud, Sh.,Swamy, M. Kumara,Veerasomaiah, P.,Venkatesh, N.. "Microwave-Assisted Synthesis and Antimicrobial Activity of Novel Pyrazole–Indanone Hybrid Analogs". . p. 1635 - 1639. Retrieved 2020/10/22.