2-Amino-4-(methylthio)-butyronitrile

Base Information

• Chemical Name: 2-Amino-4-(methylthio)-butyronitrile
• CAS No.: 3198-47-8
• Molecular Formula: C5H10 N2 S
• Molecular Weight: 130.214
• Hs Code.: 2930909090
• Mol file: 3198-47-8.mol

Synonyms:Butyronitrile,2-amino-4-(methylthio)- (6CI,7CI,8CI); 1-Cyano-3-(methylthio)propylamine;2-Amino-4-(methylthio)butanenitrile; 2-Amino-4-(methylthio)butyronitrile; DL-a-Amino-4-(methylthio)butyronitrile;Methioninenitrile; a-Amino-g-(methylthio)butyronitrile

Chemical Property of 2-Amino-4-(methylthio)-butyronitrile

Chemical Property:

• Boiling Point: 266.7±35.0 °C(Predicted)
• PKA: 4.99±0.35(Predicted)
• PSA: 75.11000
• Density: 1.085 g/cm3(Temp: 25 °C)
• LogP: 1.29068

Purity/Quality:

98%Min ^*data from raw suppliers

2-AMINO-4-(METHYLSULFANYL)BUTANENITRILE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Amino-4-(methylthio)-butyronitrile

There total 12 articles about 2-Amino-4-(methylthio)-butyronitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.5%

2-hydroxy-4-(methylthio)butyronitrile (17773-41-0) → α-amino-γ-methylmercapto-butyronitrile (3198-47-8)

Guidance literature:

With ammonia; at 45 - 60 ℃; for 0.7h; under 15001.5 Torr; Temperature; Pressure; Autoclave;

Reference yield: 65.1%

hydrogen cyanide (74-90-8) + 3-(methylsulfenyl)propanal (3268-49-3) → 2,2'-bis-(2-methylmercaptoethyl)iminodiacetonitrile + α-amino-γ-methylmercapto-butyronitrile (3198-47-8) + 2-hydroxy-4-(methylthio)butyronitrile (17773-41-0)

Guidance literature:

With ammonia; water; at 55 ℃; for 0.5h;

Reference yield: 26.0%

potassium cyanide + 3-(methylsulfenyl)propanal (3268-49-3) → α-amino-γ-methylmercapto-butyronitrile (3198-47-8)

Guidance literature:

With ammonium chloride; In methanol; water; at 60 ℃;

DOI:10.1039/c6cc07530d

upstream raw materials:

3-(methylsulfenyl)propanal

sodium cyanide

potassium cyanide

2-hydroxy-4-(methylthio)butyronitrile

Downstream raw materials:

DD/LL/LD/DL-methionylmethionine

3,6-bis[2-(methylthio)ethyl]-2,5-piperazinedione

5-(2-(methylthio)ethyl)-2-thioxoimidazolidin-4-one

DL-methionine

Refernces

• 1、 -. "METHOD FOR PRODUCING METHIONINE". Page/Page column 15. . Retrieved 2020/07/07.
• 2、 Li, Qing-Hua,Li, Zhao-Feng,Tao, Jing,Li, Wan-Fang,Ren, Li-Qing,Li, Qian,Peng, Yun-Gui,Liu, Tang-Lin. "Titanium-Catalyzed Cyano-Borrowing Reaction for the Direct Amination of Cyanohydrins with Ammonia". supporting information. p. 8429 - 8433. Retrieved 2019/10/14.