Podophyllol

Base Information

• Chemical Name: Podophyllol
• CAS No.: 78339-51-2
• Molecular Formula: C22H26O8
• Molecular Weight: 418.444
• Mol file: 78339-51-2.mol

Synonyms:Podophyllol;(5R,6R,7R,8R)-6,7-Bis-hydroxymethyl-8-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxol-5-ol;

Chemical Property of Podophyllol

Chemical Property:

• PSA: 106.84000
• LogP: 1.83700

Purity/Quality:

98.5% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Podophyllol

There total 5 articles about Podophyllol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

podofilox (518-28-5) → podophyllol (78339-51-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/S0040-4039(99)01932-2

Reference yield:

podofilox (518-28-5) → neoanhydropodophyllol (62287-47-2) + podophyllol (78339-51-2)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 20 ℃; for 3h;

DOI:10.1016/S0014-827X(01)01030-8

Reference yield:

methyl podophyllotoxinate diacetate (139955-57-0) → podophyllol (78339-51-2)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 3h;

DOI:10.1016/0031-9422(91)83051-L

upstream raw materials:

methyl podophyllotoxinate diacetate

podofilox

Downstream raw materials:

Anhydropodophyllol

neoanhydropodophyllol

6-[(1R,2S,3S)-4-Ethoxycarbonyloxy-2-ethoxycarbonyloxymethyl-3-methanesulfonyloxy-1-(3,4,5-trimethoxy-phenyl)-butyl]-benzo[1,3]dioxole-5-carboxylic acid

Methanesulfonic acid (1S,2S,3R)-1,2-bis-ethoxycarbonyloxymethyl-3-(6-formyl-benzo[1,3]dioxol-5-yl)-3-(3,4,5-trimethoxy-phenyl)-propyl ester

Refernces

• 1、 Gordaliza, Marina,Miguel Del Corral, Jose M.,Angeles Castro,Garcia-Garcia, Pablo A.,San Feliciano, Arturo. "Cytotoxic cyclolignans related to podophyllotoxin". . p. 297 - 304. Retrieved 2007/10/03.
• 2、 Mitra, Jayati,Mitra, Alok Kumar. "Carbon-13 NMR Chemical Shifts of some Podophyllum Lignans and Analogues". . p. 692 - 694. Retrieved 2007/10/03.