CYCLOPROPANESULFONIC ACID TERT-BUTYLAMIDE

Base Information

• Chemical Name: CYCLOPROPANESULFONIC ACID TERT-BUTYLAMIDE
• CAS No.: 630421-42-0
• Molecular Formula: C7H15NO2S
• Molecular Weight: 177.26400
• Hs Code.: 2935009090
• Mol file: 630421-42-0.mol

Synonyms:

Chemical Property of CYCLOPROPANESULFONIC ACID TERT-BUTYLAMIDE

Chemical Property:

• Melting Point: 81-83℃
• Boiling Point: 255℃
• PKA: 11.88±0.20(Predicted)
• Flash Point: 108℃
• PSA: 54.55000
• Density: 1.14
• LogP: 2.33840
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-tert-Butylcyclopropanesulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CYCLOPROPANESULFONIC ACID TERT-BUTYLAMIDE

There total 6 articles about CYCLOPROPANESULFONIC ACID TERT-BUTYLAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-tert-butyl-(3-chloro)propylsulfonamide (63132-85-4) → N-t-butyl-1-cyclopropylsulfonamide (630421-42-0)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 3h;

Reference yield: 95.0%

cyclopropanesulfonyl chloride (139631-62-2) + tert-butylamine (75-64-9) → N-t-butyl-1-cyclopropylsulfonamide (630421-42-0)

Guidance literature:

In tetrahydrofuran; at -20 - 20 ℃; for 24h;

Reference yield: 86.0%

cyclopropanesulphonamide (154350-29-5) + di-tert-butyl oxalate (691-64-5) → N-t-butyl-1-cyclopropylsulfonamide (630421-42-0)

Guidance literature:

With copper(II) bis(trifluoromethanesulfonate); In 1,2-dichloro-ethane; at 40 ℃; for 12h; Sealed tube; Schlenk technique;

DOI:10.1021/acs.orglett.0c04206

upstream raw materials:

N-tert-butyl-(3-chloro)propylsulfonamide

3-chloro-n-propanesulfonyl chloride

tert-butylamine

cyclopropanesulfonyl chloride

Downstream raw materials:

N-tert-butyl-1-ethyl-cyclopropanesulfonamide

N-(tert-butyl)-1-methylcyclopropane-1-sulfonamide

Refernces

• 1、 Gong, Yuxin,Zhu, Zhaodong,Qian, Qun,Tong, Weiqi,Gong, Hegui. "Zn- And Cu-catalyzed coupling of tertiary alkyl bromides and oxalates to forge challenging C?O, C?S, and C?N bonds". supporting information. p. 1005 - 1010. Retrieved 2021/02/01.
• 2、 -. "ANTIVIRAL PYRIDOPYRAZINEDIONE COMPOUNDS". Paragraph 0596-0597. . Retrieved 2020/04/09.