1-(Benzyloxy)-4-bromo-2-methoxybenzene

Base Information

• Chemical Name: 1-(Benzyloxy)-4-bromo-2-methoxybenzene
• CAS No.: 63057-72-7
• Molecular Formula: C14H13BrO2
• Molecular Weight: 293.16
• Hs Code.: 2909309090
• European Community (EC) Number: 659-482-1
• DSSTox Substance ID: DTXSID80394191
• Wikidata: Q82193445
• Mol file: 63057-72-7.mol

Synonyms:1-(BENZYLOXY)-4-BROMO-2-METHOXYBENZENE;63057-72-7;4-bromo-2-methoxy-1-phenylmethoxybenzene;MFCD00092521;SCHEMBL1447864;DTXSID80394191;AEGJXXCGTFMRGY-UHFFFAOYSA-N;4-benzyloxy-3-methoxy-bromobenzene;4-(benzyloxy)-3-methoxy-bromobenzene;2-(BENZYLOXY)-5-BROMOANISOLE;AKOS005215791;1-Benzyloxy-4-bromo-2-methoxy-benzene;AB03320;DS-18651;SY101871;CS-0061925;W17155;A868257

Chemical Property of 1-(Benzyloxy)-4-bromo-2-methoxybenzene

Chemical Property:

• PSA: 18.46000
• LogP: 4.03670
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 292.00989
• Heavy Atom Count: 17
• Complexity: 216

Purity/Quality:

98% ^*data from raw suppliers

1-(Benzyloxy)-4-bromo-2-methoxybenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=CC(=C1)Br)OCC2=CC=CC=C2

Technology Process of 1-(Benzyloxy)-4-bromo-2-methoxybenzene

There total 5 articles about 1-(Benzyloxy)-4-bromo-2-methoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-bromoguaiacol (7368-78-7) + benzyl bromide (100-39-0) → 2-benzyloxy-5-bromoanisole (63057-72-7)

Guidance literature:

With caesium carbonate; In acetone; for 4h; Heating / reflux;

Reference yield:

benzyl bromide (100-39-0) + 5-bromo-2-hydroxybenzyl alcohol (2316-64-5) → 2-benzyloxy-5-bromoanisole (63057-72-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

4-bromoguaiacol (7368-78-7) + benzyl chloride (100-44-7) → 2-benzyloxy-5-bromoanisole (63057-72-7)

Guidance literature:

With potassium carbonate; acetone;

DOI:10.1021/ja01214a013

upstream raw materials:

4-bromoguaiacol

benzyl chloride

3-methoxy-4-benzyloxybenzoyl chloride

benzyl bromide

Downstream raw materials:

ethyl 2,3,3-tri(4-benzyloxy-3-methoxyphenyl)prop-2-enoate

4,4',4''-(3-hydroxypropane-1,1,2-triyl)tris(2-methoxyphenol)

ethyl 2,3,3-tri-(4-hydroxy-3-methoxyphenyl)propanoate

2,3,3-tris(4-(benzyloxy)-3-methoxyphenyl)propan-1-ol

Refernces

• 1、 Rao, Maddali L. N.,Murty, Venneti N.,Nand, Sachchida. "Rapid Bis-Coupling Reactivity with Triarylbismuth Reagents: Synthesis of Structurally Diverse Scaffolds and Step-economic Convergent Synthesis of Quebecol". . p. 1629 - 1636. Retrieved 2020/03/05.
• 2、 -. "AZAINDOLE COMPOUNDS AS HISTONE METHYLTRANSFERASE INHIBITORS". Page/Page column 76. . Retrieved 2019/01/06.