Sarcosine

Base Information

• Chemical Name: Sarcosine
• CAS No.: 25951-24-0
• Deprecated CAS: 783292-49-9
• Molecular Formula: C3H7NO2
• Molecular Weight: 1042.23
• European Community (EC) Number: 203-538-6,270-156-4,636-764-2
• NSC Number: 118114
• UNII: Z711V88R5F
• DSSTox Substance ID: DTXSID1047025
• Nikkaji Number: J5.067I
• Wikipedia: Sarcosine
• Wikidata: Q414157
• NCI Thesaurus Code: C113501
• RXCUI: 1362906
• Metabolomics Workbench ID: 37173
• ChEMBL ID: CHEMBL304383
• Mol file: 25951-24-0.mol

Synonyms:Magnesium Sarcosylate;Methylglycine;N Methylglycine;N-Methylglycine;Sarcosinate, Sodium;Sarcosine;Sarcosine Hydrochloride;Sarcosine Monosodium Salt;Sarcosylate, Magnesium;Sodium Sarcosinate

Chemical Property of Sarcosine

Chemical Property:

• Boiling Point: 195.1°Cat760mmHg
• Flash Point: 71.8°C
• Density: 1.093g/cm³
• XLogP3: -2.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 89.047678466
• Heavy Atom Count: 6
• Complexity: 52.8

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Biological Agents -> Amino Acids and Derivatives
• Canonical SMILES: CNCC(=O)O
• Recent ClinicalTrials: Effect of Sarcosine on Symptomatology, Quality of Life, Oxidative Stress and Glutamatergic Parameters in Schizophrenia

Technology Process of Sarcosine

There total 105 articles about Sarcosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

hydrogenchloride (7647-01-0,15364-23-5) + N-methyl-N-phenylmethanesulfonyl-glycine (859960-32-0) → sarcosine (107-97-1,25951-24-0) + benzyl chloride (100-44-7)

Guidance literature:

Reference yield:

methoxycarbonylmethylamine (616-34-2) → morpholine-2,5-dione (34037-21-3) + sarcosine (107-97-1,25951-24-0) + N-methylglycine methylester (5473-12-1) + dimethyl iminodiacetate (6096-81-7) + glycine (56-40-6,18875-39-3,25718-94-9)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; at 180 ℃; for 0.166667h; under 300.03 Torr;

DOI:10.1134/S0012500818110071

Reference yield:

perthamide C → sarcosine (107-97-1,25951-24-0) + O-methyl-L-threonine (4144-02-9) + o-hydroxyl-phenylalanine (7423-92-9) + cis-4-methyl-(S)-proline (6734-41-4)

Guidance literature:

With hydrogenchloride; water; at 130 ℃;

DOI:10.1016/j.tet.2009.10.026

upstream raw materials:

creatinine

formaldehyd

methylamine hydrochloride

potassium cyanide

Downstream raw materials:

N-methyl-N-undecanoyl-glycine

1-methyl-3-phenyl-2,4-imidazolidinedione

Z-Gly-Sar-OH

N-carbamoylsarcosine

Refernces

• 1、 Carlson, Jonathan C. T.,Haider, Maximilian,Herrmann, Barbara,Klubnick, Jenna,Mikula, Hannes,Sohr, Barbara,Weissleder, Ralph,Wilkovitsch, Martin. "A Cleavable C2-Symmetric trans-Cyclooctene Enables Fast and Complete Bioorthogonal Disassembly of Molecular Probes". supporting information. p. 19132 - 19141. Retrieved 2020/11/13.
• 2、 Shevchenko,Andreeva,Nagaev, I. Yu.,Myasoedov. "Synthesis of Deuterated or Tritiated Glycine and Its Methyl Ester". . p. 266 - 267. Retrieved 2019/01/03.