2-Bromo-4-nitro-naphthalen-1-ylamine

Base Information

• Chemical Name: 2-Bromo-4-nitro-naphthalen-1-ylamine
• CAS No.: 63240-26-6
• Molecular Formula: C10H7BrN2O2
• Molecular Weight: 267.07900
• Mol file: 63240-26-6.mol

Synonyms:2-Brom-4-nitro-1-amino-naphthalin;1-Naphthalenamine,2-bromo-4-nitro;2-Bromo-4-nitro-1-naphthylamine;2-Brom-4-nitro-1-naphthylamin;1-Amino-2-Bromo-4-nitronaphthalene;1-Amino-2-brom-4-nitro-naphthalin;4-amino-3-bromo-1-nitronaphthalene;

Chemical Property of 2-Bromo-4-nitro-naphthalen-1-ylamine

Chemical Property:

• Melting Point: 250 °C
• Boiling Point: 436.0±35.0 °C(Predicted)
• PKA: -1.84±0.10(Predicted)
• PSA: 71.84000
• Density: 1.735±0.06 g/cm3(Predicted)
• LogP: 4.19710
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2-Bromo-4-nitro-naphthalen-1-ylamine 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Bromo-4-nitro-naphthalen-1-ylamine

There total 6 articles about 2-Bromo-4-nitro-naphthalen-1-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-amino-4-nitronaphthalene (776-34-1) → 2-bromo-4-nitronaphthalen-1-amine (63240-26-6)

Guidance literature:

With N-Bromosuccinimide; ammonium acetate; In acetonitrile; at 20 ℃; for 0.166667h;

DOI:10.1016/j.bmcl.2016.10.083

Reference yield:

1-acetamidonaphthalene (575-36-0) → 2-bromo-4-nitronaphthalen-1-amine (63240-26-6)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) (nitration), (ii) aq. H₂SO₄

2: Br₂ / acetic acid

With bromine; In acetic acid;

Reference yield:

→ 2-bromo-4-nitronaphthalen-1-amine (63240-26-6)

Guidance literature:

With bromine; potassium bromide;

DOI:10.1039/jr9340001705

upstream raw materials:

1-amino-4-nitronaphthalene

nitrobenzene

acetic acid

1-acetamidonaphthalene

Downstream raw materials:

3-bromonaphthalen-1-amine

3-bromo-1-hydroxynaphthalene

3-bromo-1-nitronaphthalene

Refernces

• 1、 -. "PYRIMIDINEDIONE DERIVATIVES". Page/Page column 78. . Retrieved 2021/04/10.
• 2、 Yasuda, Daisuke,Nakajima, Mao,Yuasa, Akihiro,Obata, Rika,Takahashi, Kyoko,Ohe, Tomoyuki,Ichimura, Yoshinobu,Komatsu, Masaaki,Yamamoto, Masayuki,Imamura, Riyo,Kojima, Hirotatsu,Okabe, Takayoshi,Nagano, Tetsuo,Mashino, Tadahiko. "Synthesis of Keap1-phosphorylated p62 and Keap1-Nrf2 protein-protein interaction inhibitors and their inhibitory activity". supporting information. p. 5956 - 5959. Retrieved 2016/12/14.