N'-methacryloyl-ethylenediamine

Base Information

• Chemical Name: N'-methacryloyl-ethylenediamine
• CAS No.: 63298-57-7
• Molecular Formula: C6H12N2O
• Molecular Weight: 128.174
• Hs Code.: 2924199090
• DSSTox Substance ID: DTXSID80436202
• Nikkaji Number: J1.000.902B
• Wikidata: Q82251454
• Mol file: 63298-57-7.mol

Synonyms:63298-57-7;N'-methacryloyl-ethylenediamine;n-(2-aminoethyl)methacrylamide;N-(2-AMINOETHYL)-2-METHYLPROP-2-ENAMIDE;2-Propenamide, N-(2-aminoethyl)-2-methyl-;N-aminoethylmethacrylamide;N-aminoethyl methacrylamide;SCHEMBL50166;n-(2-aminoethyl) methacrylamide;DTXSID80436202;RFZRLVGQBIINKQ-UHFFFAOYSA-N;AKOS006346002;EN300-6487159

Chemical Property of N'-methacryloyl-ethylenediamine

Chemical Property:

• Boiling Point: 298.6±32.0 °C(Predicted)
• PKA: 14.61±0.46(Predicted)
• PSA: 58.61000
• Density: 0.970±0.06 g/cm3(Predicted)
• LogP: 1.17800
• XLogP3: -0.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 128.094963011
• Heavy Atom Count: 9
• Complexity: 120

Purity/Quality:

99% ^*data from raw suppliers

N-(2-Aminoethyl)methacrylamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=C)C(=O)NCCN

Technology Process of N'-methacryloyl-ethylenediamine

There total 5 articles about N'-methacryloyl-ethylenediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.6%

<<(2-methyl-1-oxo-2-propenyl)amino>ethyl>-carbamic acid tert-butylester (206554-56-5) → N'-methacryloyl-ethylenediamine (63298-57-7)

Guidance literature:

With hydrogenchloride; In diethyl ether; water; at 20 ℃; for 24h;

DOI:10.1021/acs.biomac.9b00611

Reference yield:

Methacryloyl chloride (920-46-7,26937-45-1) → N'-methacryloyl-ethylenediamine (63298-57-7)

Guidance literature:

With sodium bicarbonate; ethylenediamine; In chloroform;

Reference yield:

Methacryloyl chloride (920-46-7,26937-45-1) → N-t-BOC + N'-methacryloyl-ethylenediamine (63298-57-7)

Guidance literature:

With sodium hydroxide; In chloroform;

upstream raw materials:

methacrylic acid N-hydroxysuccinimide ester

ethylenediamine

Methacryloyl chloride

<<(2-methyl-1-oxo-2-propenyl)amino>ethyl>-carbamic acid tert-butylester

Downstream raw materials:

N-methyl, N'-methacryloyl-ethylenediamine monohydrochloride

Refernces

• 1、 Koide, Hiroyuki,Fukuta, Tatsuya,Okishim, Anna,Ariizumi, Saki,Kiyokawa, Chiaki,Tsuchida, Hiroki,Nakamoto, Masahiko,Yoshimatsu, Keiichi,Ando, Hidenori,Dewa, Takehisa,Asai, Tomohiro,Oku, Naoto,Hoshino, Yu,Shea, Kenneth J.. "Engineering the Binding Kinetics of Synthetic Polymer Nanoparticles for siRNA Delivery". . p. 3648 - 3657. Retrieved 2019/10/16.
• 2、 -. "Propenamide derivatives containing Arg-Gly-Asp polymers obtained therefrom". . . Retrieved 2008/06/13.