2-Amino-1-(3-hydroxyphenyl)ethanone

Base Information

• Chemical Name: 2-Amino-1-(3-hydroxyphenyl)ethanone
• CAS No.: 90005-54-2
• Molecular Formula: C8H9NO2
• Molecular Weight: 151.165
• DSSTox Substance ID: DTXSID80237993
• Nikkaji Number: J35.856H
• Wikidata: Q83120254
• Mol file: 90005-54-2.mol

Synonyms:2-Amino-1-(3-hydroxyphenyl)ethanone;90005-54-2;BRN 2717281;3-Hydroxy-omega-aminoacetophenone;Ethanone, 2-amino-1-(3-hydroxyphenyl)-;4-14-00-00544 (Beilstein Handbook Reference);SCHEMBL2178782;DTXSID80237993;alpha-Amino-3'-hydroxyacetophenone;2-amino-1-(3-hydroxyphenyl)ethan-1-one;LS-67124;EN300-1858676

Chemical Property of 2-Amino-1-(3-hydroxyphenyl)ethanone

Chemical Property:

• Vapor Pressure: 3.06E-05mmHg at 25°C
• Melting Point: 217–220°C
• Boiling Point: 345.5°Cat760mmHg
• Flash Point: 162.8°C
• PSA: 63.32000
• Density: 1.228g/cm³
• LogP: 1.23390
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 151.063328530
• Heavy Atom Count: 11
• Complexity: 147

Purity/Quality:

99%min ^*data from raw suppliers

3-HYDROXY-OMEGA-AMINOACETOPHENONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=CC(=C1)O)C(=O)CN

Technology Process of 2-Amino-1-(3-hydroxyphenyl)ethanone

There total 7 articles about 2-Amino-1-(3-hydroxyphenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-azido-1-(3-hydroxyphenyl)ethan-1-one (344359-52-0) → 2-amino-1-(3-hydroxyphenyl)ethyl ketone (90005-54-2)

Guidance literature:

With hydrogenchloride; hydrogen; platinum on activated charcoal; In methanol;

DOI:10.1016/S0960-894X(01)00079-8

Reference yield:

2-bromo-1-(3-hydroxyphenyl)ethanone (2491-37-4) → 2-amino-1-(3-hydroxyphenyl)ethyl ketone (90005-54-2)

Guidance literature:

Multi-step reaction with 2 steps

1: NaN₃; CH₃N[(CH₂)7CH₃]3Cl / toluene / 55 °C

2: H₂; HCl / Pt/C / methanol

With hydrogenchloride; sodium azide; hydrogen; Aliquat 336; platinum on activated charcoal; In methanol; toluene;

DOI:10.1016/S0960-894X(01)00079-8

Reference yield:

2-amino-1-(3-benzoyloxy-phenyl)-ethanone → 2-amino-1-(3-hydroxyphenyl)ethyl ketone (90005-54-2)

Guidance literature:

With hydrogenchloride;

DOI:10.1007/BF00899309

upstream raw materials:

hexamethylenetetramine

1,1,2,2-tetrachloroethane

2-azido-1-(3-hydroxyphenyl)ethan-1-one

2-bromo-1-(3-hydroxyphenyl)ethanone

Downstream raw materials:

m-hydroxy-α-[(isopropylamino)methyl]benzyl alcohol

2-benzylidenamino-1-(3-hydroxy-phenyl)-ethanol

C₂₅H₃₃NO₄

N-[3-cyano-4-(3-hydroxy-phenyl)-1H-pyrrol-2-yl]-formamidine

Refernces