2,5-Dimethylpyrrolidine hydrochloride

Base Information

• Chemical Name: 2,5-Dimethylpyrrolidine hydrochloride
• CAS No.: 63639-02-1
• Molecular Formula: C₆H₁₃N*ClH
• Molecular Weight: 135.637
• European Community (EC) Number: 823-380-7,891-214-0
• Mol file: 63639-02-1.mol

Synonyms:63639-02-1;2,5-dimethylpyrrolidine hydrochloride;2,5-Dimethyl-pyrrolidine hydrochloride;2,5-dimethylpyrrolidine;hydrochloride;MFCD22052744;114143-75-8;MFCD01249058;MFCD01249057;rac trans-2,5-Dimethylpyrrolidine x HCl;trans-2,5-Dimethyl-pyrrolidine hydrochloride;(trans)-2,5-dimethylpyrrolidine hydrochloride;rel-(2R,5R)-2,5-Dimethylpyrrolidine hydrochloride;SCHEMBL455979;AFHNFHHYTYQLIO-UHFFFAOYSA-N;cis-2,5-Dimethylpyrrolidine x HCl;2,5-Dimethyl-pyrrolidinehydrochloride;AKOS026742037;SB30827;SB33229;SB37127;SB38062;SB38387;PS-18037;SY140252;FT-0667541;FT-0667542;D96806;EN300-105923;A901627;Z1413780490

Chemical Property of 2,5-Dimethylpyrrolidine hydrochloride

Chemical Property:

• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 135.0814771
• Heavy Atom Count: 8
• Complexity: 53.2

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1CCC(N1)C.Cl

Technology Process of 2,5-Dimethylpyrrolidine hydrochloride

There total 7 articles about 2,5-Dimethylpyrrolidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-aminohex-5-ene (7380-76-9,73604-43-0) → trans-2,5-Dimethylpyrrolidine Hydrochloride (4209-65-8,4832-49-9,63639-02-1,70144-18-2,114143-75-8,138133-34-3)

Guidance literature:

2-aminohex-5-ene; With 1,3-bis(2-iPrC₆H₄)-2-bis(TMS)N-2,1,3-scandiadiazolidine; In benzene; at 60 ℃; for 3h;

With hydrogenchloride; In diethyl ether; benzene; at -15 ℃;

DOI:10.1021/ol051574h

Reference yield: 80.0%

trans-N-(Carbobenzyloxy)-2,5-dimethylpyrrolidine (78329-37-0) → trans-2,5-Dimethylpyrrolidine Hydrochloride (4209-65-8,4832-49-9,63639-02-1,70144-18-2,114143-75-8,138133-34-3)

Guidance literature:

With hydrogenchloride; In acetic acid;

DOI:10.1021/jo00332a036

Reference yield:

(1-phenylethyl)-2,5-dimethylpyrrolidine → (2R,5S)-2,5-dimethyltetrahydro-1H-1-pyrrolylidium chloride (4209-65-8) + trans-2,5-Dimethylpyrrolidine Hydrochloride (4209-65-8,4832-49-9,63639-02-1,70144-18-2,114143-75-8,138133-34-3)

Guidance literature:

With hydrogen; palladium dihydroxide; In diethyl ether; for 28h; under 1551.4 Torr; Title compound not separated from byproducts;

DOI:10.1016/S0040-4020(01)85010-9

upstream raw materials:

trans-N-(Carbobenzyloxy)-2,5-dimethylpyrrolidine

2-aminohex-5-ene

hex-5-en-2-one oxime

(E)-hex-5-en-2-one oxime

Downstream raw materials:

2,5-dimethyl-1-(phenylethynyl)-pyrrolidine

cis-N-benzyl-2,5-dimethylpyrrolidine

Refernces

• 1、 Boga,Manescalchi,Savoia. "Diastereoselective synthesis of 2,5-dimethylpyrrolidines and 2,6- dimethylpiperidines by reductive amination of 2,5-hexanedione and 2,6- heptanedione with hydride reagents". . p. 4709 - 4722. Retrieved 2007/10/02.