Benzeneacetaldehyde, a-acetyl-

Base Information

• Chemical Name: Benzeneacetaldehyde, a-acetyl-
• CAS No.: 63726-68-1
• Molecular Formula: C10H10O2
• Molecular Weight: 162.188
• Mol file: 63726-68-1.mol

Synonyms:

Chemical Property of Benzeneacetaldehyde, a-acetyl-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzeneacetaldehyde, a-acetyl-

There total 6 articles about Benzeneacetaldehyde, a-acetyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

trans-2-acetyl-3-phenyloxirane (6249-79-2,57134-72-2,84033-96-5,144667-51-6,144667-52-7,146388-50-3,192047-39-5) → 3-Oxo-2-phenylbutanal (63726-68-1)

Guidance literature:

With lithium perchlorate; In diethyl ether; at 20 ℃; for 0.5h;

DOI:10.1039/a905619j

Reference yield: 72.0%

1-(3-phenyloxiran-2-yl)ethanone (6249-79-2,57134-72-2,84033-96-5,144667-51-6,144667-52-7,146388-50-3,192047-39-5) → 3-Oxo-2-phenylbutanal (63726-68-1)

Guidance literature:

With indium(III) chloride; In tetrahydrofuran; for 1h; Heating;

DOI:10.1021/jo980793w

Reference yield:

[benzyl-((E)-3-oxo-2-phenylbut-1-enyl)amino]methylphosphonic acid diethyl ester (1346254-67-8) → 3-Oxo-2-phenylbutanal (63726-68-1) + benzylaminomethylphosphonic acid ethyl ester (1346254-64-5)

Guidance literature:

With sodium hydride; In dimethyl sulfoxide; benzene; at 20 ℃; for 72h; Inert atmosphere;

DOI:10.1080/10426507.2011.590168

upstream raw materials:

Methyl formate

1-phenyl-acetone

formic acid ethyl ester

1-(3-phenyloxiran-2-yl)ethanone

Downstream raw materials:

5-methyl-4-phenylisoxazole

3-Methyl-4-phenyl-1H-pyrazole

1-phenyl-propane-1,2-dione-1-phenylhydrazone

3-phenylbut-3-en-2-one

Refernces

• 1、 Cal, Dariusz,Zagorski, Piotr. "Synthesis of phosphorylated enaminoketones and their application in the preparation of trifluoromethyl-functionalized 2-phosphonopyrroles". experimental part. p. 2295 - 2302. Retrieved 2012/04/10.
• 2、 Ranu, Brindaban C.,Jana, Umasish. "Indium(III) chloride-promoted rearrangement of epoxides: A selective synthesis of substituted benzylic aldehydes and ketones". . p. 8212 - 8216. Retrieved 2007/10/03.