1-broMo-2-Methylbut-3-en-2-ol

Base Information

• Chemical Name: 1-broMo-2-Methylbut-3-en-2-ol
• CAS No.: 36219-40-6
• Molecular Formula: C5H9BrO
• Molecular Weight: 165.03
• Mol file: 36219-40-6.mol

Synonyms:1-Brom-2-methyl-but-3-en-2-ol;isoprene bromohydrin;1-bromo-2-methyl-3-buten-2-ol;1-bromo-2-methyl-but-3-en-2-ol;4-Brom-3-hydroxy-3-methyl-1-buten;Isoprenbromhydrin;

Chemical Property of 1-broMo-2-Methylbut-3-en-2-ol

Chemical Property:

• PSA: 20.23000
• LogP: 1.31830
• Solubility.: DCM, DMSO, Ethyl Acetate, Methanol

Purity/Quality:

99% ^*data from raw suppliers

Isoprene Bromohydrin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Isoprene Bromohydrin is used in the synthesis of new retinoid analogs.

Technology Process of 1-broMo-2-Methylbut-3-en-2-ol

There total 7 articles about 1-broMo-2-Methylbut-3-en-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

isoprene (78-79-5,9003-31-0) → 1-bromo-2-hydroxy-2-methyl-3-butene (36219-40-6)

Guidance literature:

With N-Bromosuccinimide; water; In diethyl ether; for 12h; Ambient temperature;

DOI:10.1021/ja00360a013

Reference yield: 42.0%

isoprene (78-79-5,9003-31-0) → 1,4-dibromo-2-methylbut-2-ene (18860-95-2) + 1-bromo-2-hydroxy-2-methyl-3-butene (36219-40-6)

Guidance literature:

With hydrogen bromide; dihydrogen peroxide; at 40 ℃; for 3h;

DOI:10.1007/BF00470013

Reference yield:

isoprene (78-79-5,9003-31-0) → 4-bromo-3-methylbut-2-en-1-ol (59499-36-4) + 1-bromo-2-hydroxy-2-methyl-3-butene (36219-40-6)

Guidance literature:

With N-Bromosuccinimide; water; at 10 ℃; Temperature; Overall yield = 93.8 percent; Overall yield = 113 g;

upstream raw materials:

isoprene

N-bromoacetamide

ethanol

bromine

Downstream raw materials:

2-phenylpent-4-en-2-ol

(2E)-2-methyl-2-penten-1-ol

(Z)-2-methyl-2-penten-1-ol

(E)-2-methyl-4-phenyl-but-2-en-1-ol

Refernces

• 1、 Kim, Dahye,Shi, Gaosheng,Kim, Yunji,Koo, Sangho. "Fast Assembly and High-Throughput Screening of Structure and Antioxidant Relationship of Carotenoids". supporting information. p. 714 - 718. Retrieved 2019/01/25.
• 2、 Ritter, Helmut,Tabatabai, Monir,Herrmann, Markus. "Amino-functionalized (meth)acryl polymers by use of a solvent-polarity sensitive protecting group (Br-t-BOC)". . p. 245 - 252. Retrieved 2016/04/05.