1-(6-nitro-1H-indazol-1-yl)ethanone

Base Information

• Chemical Name: 1-(6-nitro-1H-indazol-1-yl)ethanone
• CAS No.: 13436-57-2
• Molecular Formula: C9H7N3O3
• Molecular Weight: 205.173
• Mol file: 13436-57-2.mol

Synonyms:

Chemical Property of 1-(6-nitro-1H-indazol-1-yl)ethanone

Chemical Property:

• Vapor Pressure: 9.96E-07mmHg at 25°C
• Boiling Point: 403.7°Cat760mmHg
• Flash Point: 198°C
• Density: 1.48g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(6-nitro-1H-indazol-1-yl)ethanone

There total 4 articles about 1-(6-nitro-1H-indazol-1-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.1%

→ 1-(6-nitro-1H-indazol-1-yl)ethanone (13436-57-2)

Guidance literature:

With triethylamine; In tetrahydrofuran; for 20h;

Reference yield: 75.0%

acetic anhydride (108-24-7) + 6-nitroindazole (7597-18-4) → 1-(6-nitro-1H-indazol-1-yl)ethanone (13436-57-2)

Guidance literature:

With 18-crown-6 ether; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield:

2-methyl-5-nitroaniline (99-55-8) → 1-(6-nitro-1H-indazol-1-yl)ethanone (13436-57-2)

Guidance literature:

Multi-step reaction with 2 steps

1: glacial acetic acid; sodium nitrite / durch Diazotieren

With acetic acid; sodium nitrite;

upstream raw materials:

2-acetyl-6-nitro-2H-indazole

acetic anhydride

6-nitroindazole

2-methyl-5-nitroaniline

Downstream raw materials:

1-(6-amino-1H-indazol-1-yl)ethanone

Refernces

• 1、 -. "THIENO[3,2-D]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES". Paragraph 0639; 0640; 0641. . Retrieved 2015/01/06.