2β,17β-Diacetoxyandrost-4-en-3-one

Base Information

• Chemical Name: 2β,17β-Diacetoxyandrost-4-en-3-one
• CAS No.: 21936-08-3
• Molecular Formula: C23H32O5
• Molecular Weight: 388.4972
• Mol file: 21936-08-3.mol

Synonyms:2.α.-Hydroxytestosterone, diacetate;

Chemical Property of 2β,17β-Diacetoxyandrost-4-en-3-one

Chemical Property:

• Vapor Pressure: 1.02E-09mmHg at 25°C
• Boiling Point: 489.2°Cat760mmHg
• Flash Point: 210.6°C
• PSA: 69.67000
• Density: 1.17g/cm³
• LogP: 3.99160

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A protected metabolite of Testosterone (T155000) in human.

Technology Process of 2β,17β-Diacetoxyandrost-4-en-3-one

There total 9 articles about 2β,17β-Diacetoxyandrost-4-en-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.4%

testosterone acetate (1045-69-8) + lead(IV) tetraacetate (546-67-8) → 2β,17β-Diacetoxy-androst-4-en-3-on (21936-10-7) + 2α,17β-Diacetoxyandrost-4-en-3-one (21936-08-3)

Guidance literature:

In benzene; for 72h; Heating;

DOI:10.1039/c39860001089

Reference yield:

testosterone acetate (1045-69-8) + acetic acid (64-19-7,77671-22-8) → 2β,17β-Diacetoxy-androst-4-en-3-on (21936-10-7) + 2α,17β-Diacetoxyandrost-4-en-3-one (21936-08-3)

Guidance literature:

With lead(IV) acetate;

DOI:10.1021/ja01608a036 DOI:10.1021/ja01115a028

Reference yield:

→ 2β,17β-Diacetoxy-9β,10α-androst-4-en-3-on (4223-46-5,4994-53-0,6766-29-6,6827-86-7,20823-38-5,21936-08-3,21936-10-7,95720-22-2,95720-23-3)

Guidance literature:

aus 6-Brom-17β-acetoxy-9β,10α-androst-4-en-3-on beim Behandeln mit KOAc/AcOH und anschl. Chromatogr.;

upstream raw materials:

testosterone acetate

acetic acid

lead(IV) tetraacetate

Downstream raw materials:

2alpha-Hydroxytestosterone

Refernces

• 1、 Sondheimer et al.. "-". . p. 4712,4715. Retrieved 1953.