Perflutren

Base Information

• Chemical Name: Perflutren
• CAS No.: 70024-90-7
• Deprecated CAS: 218599-63-4,300408-51-9,300408-51-9
• Molecular Formula: NULL
• Hs Code.: 35029000
• European Community (EC) Number: 200-941-9,274-272-6,232-936-2
• UN Number: 2424
• UNII: CK0N3WH0SR
• DSSTox Substance ID: DTXSID9052503
• Nikkaji Number: J353K
• Wikipedia: Octafluoropropane
• Wikidata: Q412659
• NCI Thesaurus Code: C47664,C65218,C74071
• RXCUI: 283753
• Metabolomics Workbench ID: 54478
• ChEMBL ID: CHEMBL1663
• Mol file: 70024-90-7.mol

Synonyms:C3F8-gas;Definity;MRX-115;octafluoropropane;perfluoropropane;perflutren

Chemical Property of Perflutren

Chemical Property:

• Appearance/Colour: off-white to light tan powder
• PSA: 0.00000
• LogP: 0.00000
• Storage Temp.: 2-8°C
• Solubility.: H2O: 50 mg/mL, hazy, light-yellow
• Water Solubility.: Soluble in water.
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 0
• Exact Mass: 187.98722530
• Heavy Atom Count: 11
• Complexity: 120
• Transport DOT Label: Non-Flammable Gas

Purity/Quality:

99% ^*data from raw suppliers

Albumin, Human Serum ^*data from reagent suppliers

Safty Information:

• Pictogram(s): B
• Hazard Codes: B,Xn
• Statements: 21/22
• Safety Statements: 23-24/25-36/37

MSDS Files:

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: UVCB,Other Classes -> Halogenated Aliphatics,Saturated
• Canonical SMILES: C(C(F)(F)F)(C(F)(F)F)(F)F
• Recent ClinicalTrials: An Ascending Dose Comparison of MVT-100 to Definity in Healthy Volunteers
• Recent EU Clinical Trials: Human albumin treatment in adult septic shock. A phase 2, multicenter, randomized, controlled study evaluating the immune response and organ failure.
• Description: Albumin is a known carrier of fatty acids (FA). Thus control over specific FA′s for cell culture is important, as different cell lines can differ in their sensitivity to particular fatty acids. Fatty acid-free human serum albumin (HSA) is therefore useful for cell culture studies where specific fatty acid content must be strictly controlled, so that researchers can use particular fatty acids specific to their cell lines. Fatty acid-free albumin also allows for optimal and maximum binding sites for using specific fatty acids in cell culture. The use of FA-free HSA also addresses concerns about endogenous FA′s potentially in non-FA-free HSA.
• Uses: Albumin from human serum has been used in the preparation of glycated human serum albumin (gHSA) in a glucose solution. It has also been used in the study to estimate the impact of surface nanotopography and chemical composition on blood compatibility. Used for detection in immunological analyses. Can be used as an immunological challenge to activate basophils via the IgE receptor. This recombinant variant is recommended for use in absorption, distribution, metabolism, and excretion (ADME) pharmacological research; cell culture; drug delivery research; and cryopreservation of cells.

Technology Process of Perflutren

There total 1 articles about Perflutren which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

human serum albumin, complex with L-tryptophan → (S)-2-amino-2-(1H-indol-3-yl)acetic acid (630392-83-5) + human serum albumin (70024-90-7)

Guidance literature:

In phosphate buffer; at 37 ℃; pH=7.4; Equilibrium constant; Kinetics;

DOI:10.1021/ac010643c

Reference yield:

5,5'-dithiobis-(2-nitrobenzoic acid) (69-78-3) + human serum albumin (70024-90-7) → 5-thio-2-nitrobenzoic acid (15139-21-6) + 1-carboxy-2-nitrobenzene-5-mercaptyl-S-(34Cys)human serum albumin

Guidance literature:

With sodium Oleate; In phosphate buffer; at 37 ℃; pH=6.75; Further Variations:; pH-values; reagent ratios; Kinetics;

DOI:10.1248/bpb.20.452

Reference yield:

4-thiothymidine (7236-57-9) + human serum albumin (70024-90-7) → 4-thiothymidine complexed with (human serum albumin)4

Guidance literature:

In water; dimethyl sulfoxide;

DOI:10.1016/j.carres.2013.11.018

Downstream raw materials:

5-thio-2-nitrobenzoic acid

AEFAEVSK

FQNA LLVR

DLGEENFK

Refernces