4-BENZYLOXY-3-METHOXY-OMEGA-NITROSTYRENE

Base Information

• Chemical Name: 4-BENZYLOXY-3-METHOXY-OMEGA-NITROSTYRENE
• CAS No.: 63909-38-6
• Molecular Formula: C16H15NO4
• Molecular Weight: 285.299
• Hs Code.: 2909309090
• Mol file: 63909-38-6.mol

Synonyms:

Chemical Property of 4-BENZYLOXY-3-METHOXY-OMEGA-NITROSTYRENE

Chemical Property:

• Melting Point: 122-124oC
• PSA: 64.28000
• LogP: 4.04480

Purity/Quality:

99% ^*data from raw suppliers

2-Methoxy-4-[(E)-2-nitroethenyl]-1-phenylmethoxybenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-BENZYLOXY-3-METHOXY-OMEGA-NITROSTYRENE

There total 36 articles about 4-BENZYLOXY-3-METHOXY-OMEGA-NITROSTYRENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-methoxy-4-(phenylmethoxy)benzaldehyde (2426-87-1) + nitromethane (75-52-5) → 1-(benzyloxy)-2-methoxy-4-[(E)-2-nitroethenyl]benzene (63909-38-6)

Guidance literature:

With ammonium acetate; In acetic acid; at 90 ℃; for 19h;

DOI:10.1016/j.tet.2016.05.009

Reference yield: 90.8%

3-methoxy-4-(phenylmethoxy)benzaldehyde (2426-87-1) + nitromethane (75-52-5) → 3-methoxy-4-benzyloxy-ω-nitrostyrolene (63909-38-6,1860-56-6)

Guidance literature:

With ammonium acetate; at 80 ℃; for 1.5h;

Reference yield: 69.0%

nitromethane (75-52-5) + 2-(3,5-bis(benzyloxy)-4-methoxyphenyl)acetic acid (54186-42-4) → 1-(benzyloxy)-2-methoxy-4-[(E)-2-nitroethenyl]benzene (63909-38-6)

Guidance literature:

With ammonium acetate; acetic acid; at 90 ℃; for 24h;

DOI:10.1021/acs.orglett.0c00577

upstream raw materials:

3-methoxy-4-(phenylmethoxy)benzaldehyde

nitromethane

1-(3-methoxy-4-benzyloxyphenyl)-2-nitroethanol

benzyl bromide

Downstream raw materials:

(S)-1-(4-methoxymethoxybenzyl)-2-methyl-6-methoxy-7-benzyloxy-1,2,3,4-tetrahydroisoquinoline

7-(benzyloxy)-2-[(4R)-4,5-dihydro-4-(1-methylethyl)-2-oxazolyl]-6-methoxy-1,2,3,4-tetrahydroisoquinoline

2-[4,5-dihydro-4-((R)-1-methylethyl)-2-oxazolyl]-(S)-1-(4-methoxymethoxybenzyl)-6-methoxy-7-benzyloxy-1,2,3,4-tetrahydroisoquinoline

(S)-1-(4-methoxymethoxybenzyl)-2-formyl-6-methoxy-7-benzyloxy-1,2,3,4-tetrahydroisoquinoline

Refernces

• 1、 Bartel, Karin,Biel, Martin,Bracher, Franz,Chao, Yu-Kai,Chen, Cheng-Chang,Gegenfurtner, Florian A.,Geisslinger, Franz,Gerndt, Susanne,Gerwien, Aaron,Grimm, Christian,Nguyen, Ong Nam Phuong,Ortler, Carina,Schaefer, Michael,Urban, Nicole,Vollmar, Angelika M.,Zahler, Stefan,Zisis, Themistoklis,Müller, Christoph,Müller, Martin. "Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth". . p. 1119 - 27,1131. Retrieved 2021/08/19.
• 2、 -. "Full-synthetic method of racemic tetrandrine". Paragraph 0060; 0079. . Retrieved 2019/07/10.