2-Amino-5-bromonicotinic acid

Base Information

• Chemical Name: 2-Amino-5-bromonicotinic acid
• CAS No.: 52833-94-0
• Molecular Formula: C6H5BrN2O2
• Molecular Weight: 217.022
• Hs Code.: 29333990
• European Community (EC) Number: 640-143-1
• DSSTox Substance ID: DTXSID60353241
• Wikidata: Q72438711
• Mol file: 52833-94-0.mol

Synonyms:2-amino-5-bromonicotinic acid;52833-94-0;2-amino-5-bromopyridine-3-carboxylic acid;2-amino-5-bromonicotinicacid;3-Pyridinecarboxylic acid, 2-amino-5-bromo-;2-AMINO-5-BROMO-NICOTINIC ACID;MFCD01860227;528333-94-0;2-AMINO-5-BROMO-3-PYRIDINECARBOXYLIC ACID;2-Amino-5-bromonicotonic acid;2-amino-5-bromo-pyridine-3-carboxylic acid;2-Amino-5-bromo nicotinic acid;2-amino-5-bromo-3-pyridine carboxylic acid;3-Pyridinecarboxylic acid, 2-amino-5-bromo;2-amino5-bromonicotinic acid;SCHEMBL836163;5-bromo-2-aminonicotinic acid;2-Amino-5-Bromo Nicotinicacid;5-Bromo-2-Amino Nicotinic Acid;DTXSID60353241;IEPDTLRHISNBLB-UHFFFAOYSA-N;2-amino-5-bromo-3-carboxypyridine;BBL100945;CX1229;STL554739;AKOS005064141;AC-2801;CS-W002834;PB12952;SB10157;SY002955;2-amino-5-bromonicotinic acid, AldrichCPR;A7712;AM20061284;FT-0600890;EN300-113866;AJ-333/25022118;11W-0705;J-507917;Z905189356

Chemical Property of 2-Amino-5-bromonicotinic acid

Chemical Property:

• Appearance/Colour: light yellow power
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 253-255 °C
• Refractive Index: 1.685
• Boiling Point: 350.4 °C at 760 mmHg
• PKA: 2.55±0.10(Predicted)
• Flash Point: 165.7 °C
• PSA: 76.21000
• Density: 1.909 g/cm³
• LogP: 1.70570
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 215.95344
• Heavy Atom Count: 11
• Complexity: 165

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-5-bromonicotinicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=NC(=C1C(=O)O)N)Br

Technology Process of 2-Amino-5-bromonicotinic acid

There total 3 articles about 2-Amino-5-bromonicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-aminopyridin-3-carboxylic acid (5345-47-1) → 2-amino-5-bromonicotinicacid (52833-94-0)

Guidance literature:

With bromine; In acetic acid;

Reference yield:

methyl 2-amino-5-bromopyridine-3-carboxylate (50735-34-7) → 2-amino-5-bromonicotinicacid (52833-94-0)

Guidance literature:

With methanol; sodium hydroxide; at 65 ℃; for 1h;

Reference yield:

→ 2-amino-5-bromonicotinicacid (52833-94-0)

Guidance literature:

2-Amino-nicotinsaeure, Br2;

upstream raw materials:

2-aminopyridin-3-carboxylic acid

methyl 2-amino-5-bromopyridine-3-carboxylate

Downstream raw materials:

methyl 2-amino-5-bromopyridine-3-carboxylate

2-amino-5-bromo-N-methyl-nicotinamide

2-amino-5-bromo-N-phenylpyridine-3-carboxamide

2-amino-N'-benzoyl-5-bromonicotinohydrazide

Refernces

• 1、 -. "Compound constituting a hole transfer layer and an electron transfer layer of an organic light emitting diode or a method for producing the same". Paragraph 0128-0130. . Retrieved 2020/09/16.
• 2、 -. "3 - (1, 3, 4 - Oxadiazolyl) - 5 - phenoxy - pyridine derivative and its preparation method and application". Paragraph 0029; 0030; 0031. . Retrieved 2018/03/25.