(3-NITRO-PHENYL)-OXO-ACETALDEHYDE

Base Information

• Chemical Name: (3-NITRO-PHENYL)-OXO-ACETALDEHYDE
• CAS No.: 6890-77-3
• Molecular Formula: C8H5NO4
• Molecular Weight: 179.132
• Hs Code.: 2914400090
• Mol file: 6890-77-3.mol

Synonyms:2-(3-nitrophenyl)-2-oxo-acetaldehyde;m-nitrophenylglyoxal monhydrate;(3-Nitro-phenyl)-oxo-acetaldehyde;m-nitrophenylglyoxal;2-oxo-2-(3-nitrophenyl)acetaldehyde;(3-Nitro-phenyl)-glyoxal;3-Nitro-benzoylformaldehyd;

Chemical Property of (3-NITRO-PHENYL)-OXO-ACETALDEHYDE

Chemical Property:

• Vapor Pressure: 0.00115mmHg at 25°C
• Boiling Point: 300°Cat760mmHg
• Flash Point: 147.1°C
• PSA: 79.96000
• Density: 1.376g/cm³
• LogP: 1.49960

Purity/Quality:

98%min ^*data from raw suppliers

2-(3-Nitrophenyl)-2-oxoacetaldehyde 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3-NITRO-PHENYL)-OXO-ACETALDEHYDE

There total 7 articles about (3-NITRO-PHENYL)-OXO-ACETALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

water (7732-18-5) + silver nitrate + 3'-nitro-2-bromoacetophenone (2227-64-7) → 3-nitrophenylglyoxal (6890-77-3) + 3-nitrobenzoic acid (121-92-6)

Guidance literature:

Reference yield:

3-Nitroacetophenone (121-89-1) → 3-nitrophenylglyoxal (6890-77-3)

Guidance literature:

With N-Bromosuccinimide; perchloric acid; mercury(II) diacetate; at 40 ℃; Kinetics; Rate constant; Mechanism; energy data: ΔE(excit.), ΔH(excit.), ΔS(excit.); var. conc. of ketone, NBS and HClO4; reaction in the presence of MeOH (at 40 deg C);

DOI:10.1007/BF00909670

Reference yield:

1-nitro-3-vinyl-benzene (586-39-0,51209-60-0) → 3-nitrophenylglyoxal (6890-77-3)

Guidance literature:

With iodine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dimethyl sulfoxide; at 80 ℃; for 3.5h;

DOI:10.1039/c5ra05671c

upstream raw materials:

3'-nitro-2-bromoacetophenone

3-Nitroacetophenone

water

1-nitro-3-vinyl-benzene

Downstream raw materials:

6-Chloro-2-(3-nitro-phenyl)-imidazo[1,2-b]pyridazin-3-ol

6-Benzylsulfanyl-2-(3-nitro-phenyl)-imidazo[1,2-b]pyridazin-3-ol

6-(3-Nitro-phenyl)-4-oxy-1H-pyrazin-2-one

(3-nitro-phenyl)-glyoxylonitrile

Refernces

• 1、 Kuzu, Burak,Tan, Meltem,Taslimi, Parham,Gül?in, ?lhami,Ta?p?nar, Mehmet,Menges, Nurettin. "Mono- or di-substituted imidazole derivatives for inhibition of acetylcholine and butyrylcholine esterases". . p. 187 - 196. Retrieved 2019/02/06.
• 2、 De Toledo, Ian,Grigolo, Thiago A.,Bennett, James M.,Elkins, Jonathan M.,Pilli, Ronaldo A.. "Modular Synthesis of Di- A nd Trisubstituted Imidazoles from Ketones and Aldehydes: A Route to Kinase Inhibitors". . p. 14187 - 14201. Retrieved 2019/10/16.