N-Butyl-3-cyano-6-hydroxy-4-methyl-2-pyridone

Base Information

• Chemical Name: N-Butyl-3-cyano-6-hydroxy-4-methyl-2-pyridone
• CAS No.: 39108-47-9
• Molecular Formula: C11H14N2O2
• Molecular Weight: 206.244
• Hs Code.: 2926909090
• Mol file: 39108-47-9.mol

Synonyms:1-Butyl-3-cyano-6-hydroxy-4-methyl-2(1H)-pyridinone;1-Butyl-3-cyano-6-hydroxy-4-methyl-2-pyridone;

Chemical Property of N-Butyl-3-cyano-6-hydroxy-4-methyl-2-pyridone

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.555
• Boiling Point: 342.816 °C at 760 mmHg
• PKA: 3.87±0.58(Predicted)
• Flash Point: 161.129 °C
• PSA: 66.02000
• Density: 1.193 g/cm³
• LogP: 1.53408

Purity/Quality:

99.9% ^*data from raw suppliers

N-Butyl-3-cyano-6-hydroxy-4-methyl-2-pyridone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Butyl-3-cyano-6-hydroxy-4-methyl-2-pyridone

There total 8 articles about N-Butyl-3-cyano-6-hydroxy-4-methyl-2-pyridone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.7%

ethyl acetoacetate (141-97-9) + N-butylamine (109-73-9,85404-21-3) + ethyl 2-cyanoacetate (105-56-6) → 1-butyl-6-hydroxy-4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile (39108-47-9)

Guidance literature:

N-butylamine; ethyl 2-cyanoacetate; at 70 ℃; for 2h; Inert atmosphere;

ethyl acetoacetate; With piperidine; at 100 ℃; for 8h; Inert atmosphere;

Reference yield:

acetoacetic acid methyl ester (105-45-3) + methyl 2-cyanoacetate (105-34-0) → 1-butyl-6-hydroxy-4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile (39108-47-9)

Guidance literature:

With N-butylamine; In water;

Reference yield:

acetoacetic acid methyl ester (105-45-3) + N-butylamine (109-73-9,85404-21-3) + methyl 2-cyanoacetate (105-34-0) → 1-butyl-6-hydroxy-4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile (39108-47-9)

Guidance literature:

N-butylamine; methyl 2-cyanoacetate; at 100 ℃; for 5h;

acetoacetic acid methyl ester; With piperidine; at 100 ℃; for 5h;

upstream raw materials:

(Z)-4-Butylcarbamoyl-2-cyano-3-methyl-but-2-enoic acid ethyl ester

ethyl acetoacetate

cyanoacetic acid butylamide

N-butyl-3-oxobutanamide

Refernces

• 1、 -. "Fastness". Paragraph 0128; 0130; 0131. . Retrieved 2018/10/24.
• 2、 Wuerthner, Frank. "DMF in acetic anhydride: A useful reagent for multiple-component syntheses of merocyanine dyes". . p. 2103 - 2113. Retrieved 2007/10/03.