2-Chloro-6-methylpyridine

Base Information

• Chemical Name: 2-Chloro-6-methylpyridine
• CAS No.: 18368-63-3
• Molecular Formula: C6H6ClN
• Molecular Weight: 127.573
• Hs Code.: 29333990
• European Community (EC) Number: 242-241-6
• UNII: 39MX1LQ68L
• DSSTox Substance ID: DTXSID0022272
• Nikkaji Number: J100.611H
• Wikidata: Q27256919
• Mol file: 18368-63-3.mol

Synonyms:2-Chloro-6-methylpyridine;18368-63-3;6-Chloro-2-picoline;Pyridine, 2-chloro-6-methyl-;2-Chloro-6-picoline;6-Chloro-2-methylpyridine;2-Picoline, 6-chloro-;MFCD00006245;EINECS 242-241-6;6-methyl-2-chloropyridine;UNII-39MX1LQ68L;2-Chloro-6-Methyl Pyridine;39MX1LQ68L;2-Chloro-6-Methy Pyridine;2-chloro-6-methyl-pyridine;2-chloro-6-mehtylpyridine;2-chloro-6- methylpyridine;2-Cl-6-(CH3)-pyridine;SCHEMBL111063;4-(Difluoromethoxy)benzylalcohol;DTXSID0022272;2-Chloro-6-methylpyridine, 99%;STK503735;AKOS005145589;AB00666;AC-2669;CS-W001993;DS-0800;PS-6122;LS-184968;AM20070051;C1654;FT-0611883;EN300-50196;A812808;J-650119;W-206316;Q27256919;F0001-0665

Chemical Property of 2-Chloro-6-methylpyridine

Chemical Property:

• Appearance/Colour: Light yellow liquid
• Vapor Pressure: 1.05mmHg at 25°C
• Refractive Index: n20/D 1.527(lit.)
• Boiling Point: 183.5 °C at 760 mmHg
• PKA: 1.10±0.10(Predicted)
• Flash Point: 73.9 °C
• PSA: 12.89000
• Density: 1.15 g/cm³
• LogP: 2.04340
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 127.0188769
• Heavy Atom Count: 8
• Complexity: 74.9

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-6-methylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,Xn
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-36-36/37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC1=NC(=CC=C1)Cl
• Uses: 2-Chloro-6-methylpyridine has been used for experimental FTIR and FT-Raman spectroscopic analyses, as well as for conformational studies.

Technology Process of 2-Chloro-6-methylpyridine

There total 11 articles about 2-Chloro-6-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

α-picoline (109-06-8) + p-nitrophenyl isocyanide (1984-23-2) → 6-chloro-2-picoline (18368-63-3) + 6-methyl-pyridine-2-carboxylic acid (4-nitro-phenyl)-amide + 2-(6-methyl-pyridin-2-yl)-N-(4-nitro-phenyl)-2-oxo-acetamide

Guidance literature:

α-picoline; With fluorine; In dichloromethane; at -78 - -50 ℃;

p-nitrophenyl isocyanide; In dichloromethane; at -50 - 0 ℃; for 4h;

DOI:10.1016/j.tetlet.2005.02.010

Reference yield: 67.0%

2-benzyloxy-6-methylpyridine (107622-87-7) → 6-chloro-2-picoline (18368-63-3)

Guidance literature:

With N,N-dimethyl-formamide; trichlorophosphate; at 95 ℃; for 40h;

Reference yield: 66.0%

2-methoxy-6-methyl-pyridine (63071-03-4) → 6-chloro-2-picoline (18368-63-3)

Guidance literature:

With N,N-dimethyl-formamide; trichlorophosphate; at 95 ℃; for 24h;

upstream raw materials:

2-Amino-6-methylpyridine

6-hydroxy-2-methylpyridine

2-methoxy-6-methyl-pyridine

2-benzyloxy-6-methylpyridine

Downstream raw materials:

2-methyl-6-phenoxypyridine

6-hydroxy-2-methylpyridine

2-Cyano-6-methylpyridine

6-chloropicolinic acid

Refernces

• 1、 Kiselyov, Alexander S.. "Reaction of N-fluoropyridinium fluoride with isonitriles: A convenient route to picolinamides". . p. 2279 - 2282. Retrieved 2007/10/03.
• 2、 Lai, Long-Li,Lin, Pen-Yuan,Wang, Jy-Shih,Hwu, Jih Ru,Shiao, Min-Jen,Tsay, Shwu-Chen. "Substituent Effect on the Chlorination of 2-Alkoxypyridines to give 2-Chloropyridines under Vilsmeier-Haack Conditions". . p. 194 - 195. Retrieved 2007/10/03.