Ethanone, 1-(4-methylphenyl)-, hydrazone

Base Information

• Chemical Name: Ethanone, 1-(4-methylphenyl)-, hydrazone
• CAS No.: 64252-53-5
• Molecular Formula: C9H12N2
• Molecular Weight: 148.208
• Hs Code.: 2928000090
• European Community (EC) Number: 621-618-2
• DSSTox Substance ID: DTXSID60404348
• Mol file: 64252-53-5.mol

Synonyms:Ethanone, 1-(4-methylphenyl)-, hydrazone;64252-53-5;1-(4-methylphenyl)ethylidenehydrazine;DTXSID60404348

Chemical Property of Ethanone, 1-(4-methylphenyl)-, hydrazone

Chemical Property:

• PSA: 38.38000
• LogP: 2.37800
• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 148.100048391
• Heavy Atom Count: 11
• Complexity: 144

Purity/Quality:

(1-P-TOLYL-ETHYLIDENE)-HYDRAZINE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C(=NN)C

Technology Process of Ethanone, 1-(4-methylphenyl)-, hydrazone

There total 5 articles about Ethanone, 1-(4-methylphenyl)-, hydrazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

para-methylacetophenone (122-00-9) → 4-methylacetophenone hydrazone (64252-53-5)

Guidance literature:

With boron trifluoride diethyl etherate; hydrazine; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

DOI:10.1134/S1070363216120471

Reference yield: 82.0%

4-n-methylphenylacetylene (766-97-2) → 4-methylacetophenone hydrazone (64252-53-5)

Guidance literature:

With C₂₃H₃₀AuIN₂; potassium tetrakis-(3,5-bis(trifluoromethyl)phenyl)borate; hydrazine hydrate; In benzene; at 20 ℃; for 4h; Schlenk technique; Inert atmosphere;

DOI:10.1002/chem.201402560

Reference yield:

p-Methylacetophenone N,N-dimethylhydrazone (5757-88-0) → 4-methylacetophenone hydrazone (64252-53-5)

Guidance literature:

With hydrazine; In ethanol; Heating;

DOI:10.1021/jo01341a008

upstream raw materials:

para-methylacetophenone

p-Methylacetophenone N,N-dimethylhydrazone

4-n-methylphenylacetylene

Downstream raw materials:

4-Methylacetanilide

4-methylethylbenzene

1-(1,1-dibromoprop-1-en-2-yl)-4-methylbenzene

(E)-1,2-Dibromo-1-(4-methylphenyl)ethylene

Refernces

• 1、 El-Azab,Ghabbour,El-Husseiny,Maarouf,Mohamed,Abdel-Aziz. "Lewis acid-promoted direct synthesis of N-unsubstituted hydrazones via the reaction of hydrazine with acetophenone and isatin derivatives". . p. 2837 - 2844. Retrieved 2017/03/22.
• 2、 Zhang, Yan,Wang, Dahai,Cui, Sunliang. "Facile Synthesis of Isoindolinones via Rh(III)-Catalyzed One-Pot Reaction of Benzamides, Ketones, and Hydrazines". supporting information. p. 2494 - 2497. Retrieved 2015/05/27.