4-HYDROXY-CINNOLINE

Base Information

• Chemical Name: 4-HYDROXY-CINNOLINE
• CAS No.: 875-66-1
• Molecular Formula: C8H6 N2 O
• Molecular Weight: 146.148
• Hs Code.: 2933990090
• Mol file: 875-66-1.mol

Synonyms:NSC 81669

Chemical Property of 4-HYDROXY-CINNOLINE

Chemical Property:

• PSA: 46.01000
• LogP: 1.33540
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

Cinnolin-4-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-HYDROXY-CINNOLINE

There total 10 articles about 4-HYDROXY-CINNOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-Aminoacetophenone (613-89-8) → cinnolin-4-ol (875-66-1)

Guidance literature:

With hydrogenchloride; sodium nitrite; In water; at -5 - 65 ℃; for 3h;

Reference yield: 81.2%

4-Hydroxy-cinnoline-3-carboxylic acid (53512-17-7) → cinnolin-4-ol (875-66-1)

Guidance literature:

at 200 ℃; for 0.25h;

Reference yield: 73.0%

2-[(trimethylsilyl)ethynyl]aniline (103529-16-4) → cinnolin-4-ol (875-66-1)

Guidance literature:

2-[(trimethylsilyl)ethynyl]aniline; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 0.5h;

for 3h; Heating;

DOI:10.1016/S0040-4020(00)00448-8

upstream raw materials:

cinnolin-4-ylamine

4-Hydroxy-cinnoline-3-carboxylic acid

trimethylsilylacetylene

2-[(trimethylsilyl)ethynyl]aniline

Downstream raw materials:

1-[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]-1H-cinnolin-4-one

4-chloroquinoline

(4-chloro-3-cinnolinyl)-2-methoxyphenylmethanol

(4-Chloro-cinnolin-3-yl)-(2-methoxy-phenyl)-methanone

Refernces

• 1、 -. "TOLL-LIKE RECEPTOR 8 (TLR8)-SPECIFIC ANTAGONISTS AND METHODS OF MAKING AND USES THEREOF". Page/Page column 65. . Retrieved 2019/05/22.
• 2、 Gautheron Chapoulaud,Plé,Turck,Quéguiner. "Synthesis of 4,8-diarylcinnolines and quinazolines with potential applications in nonlinear optics. Diazines. Part 28". . p. 5499 - 5507. Retrieved 2007/10/03.