Technology Process of 3aα,7,7aα,8,9,9aβ-Hexahydro-4β-hydroxy-5,8β-dimethyl-3-methyleneazuleno[6,5-b]furan-2,6(3H,4H)-dione
There total 8 articles about 3aα,7,7aα,8,9,9aβ-Hexahydro-4β-hydroxy-5,8β-dimethyl-3-methyleneazuleno[6,5-b]furan-2,6(3H,4H)-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
manganese(IV) oxide;
In
dichloromethane;
at 20 ℃;
for 16h;
chemoselective reaction;
Inert atmosphere;
DOI:10.1002/anie.201611078
- Guidance literature:
-
C38H56O5Si2;
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
at 20 ℃;
for 24h;
Inert atmosphere;
With
1,8-diazabicyclo[5.4.0]undec-7-ene;
In
tetrahydrofuran; dichloromethane; toluene;
Inert atmosphere;
DOI:10.1002/anie.201611078
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium iodide; tin(ll) chloride / N,N-dimethyl-formamide / 12 h / 60 °C / Inert atmosphere
2.1: methanol; dichloromethane / 16 h / 20 °C / Inert atmosphere
2.2: 6 h / 760.05 Torr / Inert atmosphere
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere
3.2: Inert atmosphere
With
tetrabutyl ammonium fluoride; sodium iodide; tin(ll) chloride;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/anie.201611078
