Benzamide, N-[(4-methylphenyl)methoxy]-

Base Information

• Chemical Name: Benzamide, N-[(4-methylphenyl)methoxy]-
• CAS No.: 64583-56-8
• Molecular Formula: C₁₅H₁₅NO₂
• Molecular Weight: 241.29
• DSSTox Substance ID: DTXSID90368282
• Wikidata: Q82154699
• ChEMBL ID: CHEMBL1509197
• Mol file: 64583-56-8.mol

Synonyms:HMS2761N03;64583-56-8;Benzamide, N-[(4-methylphenyl)methoxy]-;MLS001007701;CHEMBL1509197;DTXSID90368282;AKOS030579248;SMR000384753;Z25686816

Chemical Property of Benzamide, N-[(4-methylphenyl)methoxy]-

Chemical Property:

• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 241.110278721
• Heavy Atom Count: 18
• Complexity: 253

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)CONC(=O)C2=CC=CC=C2

Technology Process of Benzamide, N-[(4-methylphenyl)methoxy]-

There total 5 articles about Benzamide, N-[(4-methylphenyl)methoxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

potassium benzohydroxamate (32685-16-8) + 4-Methylbenzyl bromide (104-81-4) → p-methylbenzyl benzohydroxamate (64583-56-8)

Guidance literature:

With sodium carbonate; In methanol; water;

Reference yield:

4-Methylbenzyl alcohol (589-18-4) → p-methylbenzyl benzohydroxamate (64583-56-8)

Guidance literature:

Multi-step reaction with 2 steps

1: HBr-H₂SO₄ / diethyl ether / Heating

2: 59 percent / sodium carbonate / methanol; H₂O

With sulfuric acid; hydrogen bromide; sodium carbonate; In methanol; diethyl ether; water;

Reference yield:

benzoic acid ethyl ester (93-89-0,99341-95-4) → p-methylbenzyl benzohydroxamate (64583-56-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 55 percent / potassium hydroxide, hydroxylamine hydrochloride / methanol

2: 59 percent / sodium carbonate / methanol; H₂O

With potassium hydroxide; hydroxylamine hydrochloride; sodium carbonate; In methanol; water;

upstream raw materials:

Benzohydroxamic acid

4-Methylbenzyl bromide

potassium benzohydroxamate

4-Methylbenzyl alcohol

Downstream raw materials:

O-(p-methylbenzyl)hydroxylamine

N-(acetyloxy)-N-(((4-methylphenyl)methyl)oxy)benzamide

Refernces

• 1、 Campbell, John J.,Glover, Stephen A.,Hammond, Gerard P.,Rowbottom, Colleen A.. "Evidence for the Formation of Nitrenium Ions in the Acid-catalysed Solvolysis of Mutagenic N-Acetoxy-N-Alkoxybenzamides". . p. 2067 - 2080. Retrieved 2007/10/02.