Benzeneacetic acid, a-methyl-4-(2-methylpropyl)-, 2-hydroxyethyl ester

Base Information

• Chemical Name: Benzeneacetic acid, a-methyl-4-(2-methylpropyl)-, 2-hydroxyethyl ester
• CAS No.: 64622-20-4
• Molecular Formula: C15H22O3
• Molecular Weight: 250.338
• Mol file: 64622-20-4.mol

Synonyms:

Chemical Property of Benzeneacetic acid, a-methyl-4-(2-methylpropyl)-, 2-hydroxyethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzeneacetic acid, a-methyl-4-(2-methylpropyl)-, 2-hydroxyethyl ester

There total 7 articles about Benzeneacetic acid, a-methyl-4-(2-methylpropyl)-, 2-hydroxyethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

ibuprofen (15687-27-1,58560-75-1) + ethylene glycol (107-21-1) → 2-hydroxyethyl 2-(4-isobutylphenyl)propionate (64622-20-4)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.jorganchem.2018.02.049

Reference yield: 85.0%

2-(4-Isobutyl-phenyl)-2-(1-phenyltellanyl-ethyl)-[1,3]dioxolane (91306-46-6) → 2-hydroxyethyl 2-(4-isobutylphenyl)propionate (64622-20-4)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In methanol; Ambient temperature;

DOI:10.1039/c39840000426

Reference yield: 82.0%

2-(4-Isobutyl-phenyl)-2-(1-phenylselanyl-ethyl)-[1,3]dioxolane (91306-41-1) → 2-hydroxyethyl 2-(4-isobutylphenyl)propionate (64622-20-4)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In methanol; at 20 - 25 ℃;

upstream raw materials:

2-(4-Isobutyl-phenyl)-2-(1-phenylselanyl-ethyl)-[1,3]dioxolane

2-(4-Isobutyl-phenyl)-2-(1-phenyltellanyl-ethyl)-[1,3]dioxolane

2-(1-bromoethyl)-2-[4-(2-methylpropyl)-phenyl]-1,3-dioxolane

(+/-)-2-(4-isobutylphenyl)propanoyl chloride

Downstream raw materials:

C₁₅H₂₀O₃

ibuprofen

Refernces

• 1、 Romero-Chávez, Maria M.,Pineda-Urbina, Kayim,Pérez, David J.,Obledo-Benicio, Fernando,Flores-Parra, Angelina,Gómez-Sandoval, Zeferino,Ramos-Organillo, ángel. "Organotin(IV) compounds derived from ibuprofen and cinnamic acids, an alternative into design of anti-inflammatory by the cyclooxygenases (COX-1 and COX-2) pathway". . p. 58 - 70. Retrieved 2018/03/22.
• 2、 -. "SYSTEMS AND METHODS FOR AMELIORATING THE EFFECTS OF TOBACCO PRODUCTS". Page/Page column 86. . Retrieved 2015/12/08.