Benzamide, 4-(difluoromethyl)-

Base Information

• Chemical Name: Benzamide, 4-(difluoromethyl)-
• CAS No.: 64747-70-2
• Molecular Formula: C8H7F2NO
• Molecular Weight: 171.146
• Mol file: 64747-70-2.mol

Synonyms:

Chemical Property of Benzamide, 4-(difluoromethyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzamide, 4-(difluoromethyl)-

There total 3 articles about Benzamide, 4-(difluoromethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

para-methylbenzamide (619-55-6) → 4-(difluoromethyl)benzamide (64747-70-2)

Guidance literature:

With sodium persulfate; silver nitrate; Selectfluor; In water; acetonitrile; at 80 ℃; for 5h; Inert atmosphere; Schlenk technique; Cooling with liquid nitrogen;

DOI:10.1002/anie.201400225

Reference yield:

4-(fluoromethyl)benzamide (64747-69-9) → 4-(difluoromethyl)benzamide (64747-70-2)

Guidance literature:

With sodium persulfate; silver nitrate; 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(hexafluorophosphate); In water; acetonitrile; at 80 ℃; Inert atmosphere; Schlenk technique;

DOI:10.1039/c6cc07913j

Reference yield:

4-(bromomethyl)benzamide (58914-40-2) → 4-(difluoromethyl)benzamide (64747-70-2)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / Inert atmosphere; Reflux

2: sodium persulfate; 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(hexafluorophosphate); silver nitrate / acetonitrile; water / 80 °C / Inert atmosphere; Schlenk technique

With sodium persulfate; tetrabutyl ammonium fluoride; silver nitrate; 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(hexafluorophosphate); In tetrahydrofuran; water; acetonitrile;

DOI:10.1039/c6cc07913j

upstream raw materials:

para-methylbenzamide

4-(bromomethyl)benzamide

4-(fluoromethyl)benzamide

Refernces

• 1、 Ma, Jing-Jing,Yi, Wen-Bin,Lu, Guo-Ping,Cai, Chun. "Transition-metal-free C-H oxidative activation: Persulfate-promoted selective benzylic mono- and difluorination". supporting information. p. 2890 - 2894. Retrieved 2015/04/27.