5-BROMO-2,4-DIMETHOXYPYRIMIDINE

Base Information

• Chemical Name: 5-BROMO-2,4-DIMETHOXYPYRIMIDINE
• CAS No.: 56686-16-9
• Molecular Formula: C6H7BrN2O2
• Molecular Weight: 219.038
• Hs Code.: 29335990
• Mol file: 56686-16-9.mol

Synonyms:2,4-Dimethoxy-5-bromopyrimidine;5-Bromo-2,4-bis(methyloxy)pyrimidine;5-Bromo-2,4-dimethoxypyrimidine;5-Bromo-2,6-dimethoxypyrimidine;NSC 81442;

Chemical Property of 5-BROMO-2,4-DIMETHOXYPYRIMIDINE

Chemical Property:

• Appearance/Colour: White crystalline solid
• Vapor Pressure: 0.00245mmHg at 25°C
• Melting Point: 62-65 °C(lit.)
• Refractive Index: 1.533
• Boiling Point: 297 °C at 760 mmHg
• PKA: 1.27±0.29(Predicted)
• Flash Point: 133.4 °C
• PSA: 44.24000
• Density: 1.563 g/cm³
• LogP: 1.25630
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Acetone, Dichloromethane

Purity/Quality:

99.9% ^*data from raw suppliers

5-Bromo-2,4-dimethoxypyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,Xn
• Hazard Codes: Xi,Xn
• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 5-BROMO-2,4-DIMETHOXYPYRIMIDINE

There total 9 articles about 5-BROMO-2,4-DIMETHOXYPYRIMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2,4-dimethoxypyrimidine (3551-55-1) → 5-bromo-2,4-dimethoxypyrimidine (56686-16-9)

Guidance literature:

With bromine; sodium hydrogencarbonate; In methanol; water; at 25 ℃;

DOI:10.1021/ol800353s

Reference yield: 55.0%

5,5'-Mercuri-bis-(2,4-dimethoxypyrimidine) (123551-51-9) → 5-bromo-2,4-dimethoxypyrimidine (56686-16-9)

Guidance literature:

With bromine; potassium bromide; In water; at 60 - 80 ℃; for 0.75h;

DOI:10.1007/BF00479920

Reference yield: 51.0%

5-Acetoxymercuri-2,4-dimethoxypyrimidine (123551-48-4) → 5-bromo-2,4-dimethoxypyrimidine (56686-16-9)

Guidance literature:

With bromine; potassium bromide; In water; at 60 - 80 ℃; for 0.75h;

DOI:10.1007/BF00479920

upstream raw materials:

2,4-dichloro-5-bromopyrimidine

sodium methylate

5-Acetoxymercuri-2,4-dimethoxypyrimidine

5,5'-Mercuri-bis-(2,4-dimethoxypyrimidine)

Downstream raw materials:

1,2-dihydro-5-bromo-4-methoxy-2-oxo-1-(2'-benzoyloxyethoxymethyl)pyrimidine

5-bromouracil

2,4‐dimethoxy‐5‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)pyrimidine

(2,4-dimethoxy-5-pyrimidinyl)-(4-ethylphenyl) methanol

Refernces

• 1、 Delia, Thomas J.,Hood, Robin J.. "Bromination of pyrimidines: A simple inexpensive method". . p. 254 - 255. Retrieved 2015/02/19.
• 2、 Boudet, Nadege,Dubbaka, Srinivas Reddy,Knochel, Paul. "Oxidative amination of cuprated pyrimidine and purine derivatives". supporting information; experimental part. p. 1715 - 1718. Retrieved 2009/04/10.