PIPERAZINE-2,3-DIONE

Base Information

• Chemical Name: PIPERAZINE-2,3-DIONE
• CAS No.: 13092-86-9
• Molecular Formula: C4H6 N2 O2
• Molecular Weight: 114.104
• Hs Code.: 2933599090
• Mol file: 13092-86-9.mol

Synonyms:2,3-Diketopiperazine;2,3-Dioxopiperazine; NSC 218330

Chemical Property of PIPERAZINE-2,3-DIONE

Chemical Property:

• Melting Point: 285 °C (decomp)
• Boiling Point: °Cat760mmHg
• PKA: 10.72±0.20(Predicted)
• Flash Point: °C
• PSA: 58.20000
• Density: 1.246g/cm³
• LogP: -1.11000
• Storage Temp.: 2-8°C
• Solubility.: DMSO (Slightly, Sonicated), Methanol (Slightly, Sonicated)

Purity/Quality:

98%min ^*data from raw suppliers

2,3-Piperazinedione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Total 1 MSDS from other Authors

Useful:

• Uses: 2,3-Piperazinedione is a metabolite of Ketoconazole (K186000), a broad-spectrum antifungal drug that inhibits steroid synthetic pathways and is used to treat patients with seborrheic dermatitis.

Technology Process of PIPERAZINE-2,3-DIONE

There total 4 articles about PIPERAZINE-2,3-DIONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-carboxyl-2-aminobutyrolactone (4471-04-9) + sodium thiomethoxide (5188-07-8) → diketopiperazine (13092-86-9) + DL-methionine (59-51-8,26062-47-5,58576-49-1)

Guidance literature:

In 1-methyl-pyrrolidin-2-one; at 20 - 150 ℃; for 1.16667h;

Reference yield:

2-aminobutyrolactone (1192-20-7) + sodium thiomethoxide (5188-07-8) → diketopiperazine (13092-86-9) + DL-Homoserine (1927-25-9,119736-88-8) + DL-methionine (59-51-8,26062-47-5,58576-49-1)

Guidance literature:

In 1-methyl-pyrrolidin-2-one; at 20 - 150 ℃; for 1.16667h;

Reference yield:

GlyOEt*HCl (459-73-4) → diketopiperazine (13092-86-9) + H-Gly-NH2 (598-41-4)

Guidance literature:

With ammonia; in geschlossenem Rohr;in mehrere Stufen;

upstream raw materials:

GlyOEt*HCl

2-aminobutyrolactone

sodium thiomethoxide

N-carboxyl-2-aminobutyrolactone

Downstream raw materials:

4-(2-(benzyloxy)-3-{4-[2-(benzyloxy)-3-(4-cyanophenoxy)propyl]-2,3-dioxo-1-piperazinyl}propoxy)benzonitrile

(4-butyl-2,5-dioxo-piperazin-1-yl)-acetic acid benzyl ester

1,4-dinitro-piperazine-2,3-dione

Oxalamide

Refernces

• 1、 -. "Benzofurylpiperazine serotonin agonists". . . Retrieved 2008/06/13.