2-Thiophenecarboxamide, 3-methoxy-

Base Information

• Chemical Name: 2-Thiophenecarboxamide, 3-methoxy-
• CAS No.: 78031-17-1
• Molecular Formula: C₆H₇NO₂S
• Molecular Weight: 157.193
• Mol file: 78031-17-1.mol

Synonyms:3-Methoxy-2-thiophenecarboxamide

Chemical Property of 2-Thiophenecarboxamide, 3-methoxy-

Chemical Property:

• Vapor Pressure: 0.000852mmHg at 25°C
• Boiling Point: 304.9°C at 760 mmHg
• Flash Point: 138.2°C
• PSA: 80.56000
• Density: 1.292g/cm³
• LogP: 1.55590

Purity/Quality:

99%min ^*data from raw suppliers

3-Methoxythiophene-2-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Thiophenecarboxamide, 3-methoxy-

There total 3 articles about 2-Thiophenecarboxamide, 3-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

3-methoxy-2-thenoyl chloride (54450-14-5) → 3-methoxythiophene-2-carboxamide (78031-17-1)

Guidance literature:

With ammonia; In diethyl ether; at -40 ℃; for 2h;

DOI:10.1002/ardp.19923250206

Reference yield:

methyl 3-methoxy-2-thiophenecarboxylate (62353-75-7) → 3-methoxythiophene-2-carboxamide (78031-17-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / 1M NaOH / Heating

2: SOCl₂ / dimethylformamide; benzene / 0.25 h / Heating

3: 72 percent / NH₃(liq.) / diethyl ether / 2 h / -40 °C

With sodium hydroxide; thionyl chloride; ammonia; In diethyl ether; N,N-dimethyl-formamide; benzene;

DOI:10.1002/ardp.19923250206

Reference yield:

3-methoxythiophene-2-carboxylic acid (60166-83-8) → 3-methoxythiophene-2-carboxamide (78031-17-1)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / dimethylformamide; benzene / 0.25 h / Heating

2: 72 percent / NH₃(liq.) / diethyl ether / 2 h / -40 °C

With thionyl chloride; ammonia; In diethyl ether; N,N-dimethyl-formamide; benzene;

DOI:10.1002/ardp.19923250206

upstream raw materials:

3-methoxy-2-thenoyl chloride

methyl 3-methoxy-2-thiophenecarboxylate

3-methoxythiophene-2-carboxylic acid

Refernces

• 1、 Occhipinti, Salvatore,Alberghina, Gaetano,Fisichella, Salvatore,Puglisi, Orazio,Ceraulo, Leopoldo. "The Fragmentation of 5- and 3-Substituted Thiophene-2-carboxamides Under Electron Impact". . p. 632 - 636. Retrieved 2007/10/02.