4-(2,5-Dioxopyrrolidin-1-yl)butanoic acid

Base Information

• Chemical Name: 4-(2,5-Dioxopyrrolidin-1-yl)butanoic acid
• CAS No.: 31601-68-0
• Molecular Formula: C8H11 N O4
• Molecular Weight: 185.18
• Hs Code.: 2925190090
• European Community (EC) Number: 824-808-5
• NSC Number: 192708
• DSSTox Substance ID: DTXSID90307550
• Nikkaji Number: J1.198.331F
• Wikidata: Q82054980
• Mol file: 31601-68-0.mol

Synonyms:31601-68-0;4-(2,5-dioxopyrrolidin-1-yl)butanoic acid;4-(2,5-Dioxo-pyrrolidin-1-yl)-butyric acid;NSC192708;SCHEMBL501046;DTXSID90307550;HMS1699F07;MFCD00482001;STK346853;2,5-Dioxo-1-pyrrolidinebutanoic acid;4-(2,5-Dioxopyrrolizino)butyric acid;AKOS000150730;NSC 192708;NSC-192708;4-(2,5-Dioxopyrrolidin-1-yl)butyric acid;4-(2,5-Dioxo-pyrrolidin-1-yl)-butyricacid;4-(2,5-Dioxo-pyrrolidin-1-yl)butyric acid;BB 0218448;EN300-40371;Z57818392;F1265-0247

Chemical Property of 4-(2,5-Dioxopyrrolidin-1-yl)butanoic acid

Chemical Property:

• Vapor Pressure: 5.16E-09mmHg at 25°C
• Boiling Point: 441.1°Cat760mmHg
• Flash Point: 220.6°C
• PSA: 74.68000
• Density: 1.342g/cm³
• LogP: -0.06190
• XLogP3: -1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 185.06880783
• Heavy Atom Count: 13
• Complexity: 233

Purity/Quality:

98%min ^*data from raw suppliers

4-(2,5-Dioxo-pyrrolidin-1-yl)-butyric acid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(=O)N(C1=O)CCCC(=O)O

Technology Process of 4-(2,5-Dioxopyrrolidin-1-yl)butanoic acid

There total 4 articles about 4-(2,5-Dioxopyrrolidin-1-yl)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.5%

succinic acid anhydride (108-30-5) + 4-amino-n-butyric acid (56-12-2) → 4-(2,5-dioxopyrrolidin-1-yl)butanoic acid (31601-68-0)

Guidance literature:

With acetic acid; at 100 ℃; for 3h;

Reference yield: 93.0%

indolizidin-3-one (2740-00-3,71779-55-0) → 4-(2,5-dioxopyrrolidin-1-yl)butanoic acid (31601-68-0)

Guidance literature:

With ruthenium(IV) oxide; sodium periodate; In water; ethyl acetate; for 4.5h; Ambient temperature;

Reference yield:

2-pyrrolidinon (616-45-5) + succinic acid anhydride (108-30-5) → 4-(2,5-dioxopyrrolidin-1-yl)butanoic acid (31601-68-0)

Guidance literature:

upstream raw materials:

2-pyrrolidinon

succinic acid anhydride

indolizidin-3-one

4-amino-n-butyric acid

Downstream raw materials:

N-(2-(5-(3-(2,4-dihydroxy-5-isopropylphenyl)-5-hydroxy-4H-1,2,4-triazol-4-yl)-1H-indol-1-yl)ethyl)-4-(2,5-dioxopyrrolidin-1-yl)butanamide

N-(2-(5-(3-(2,4-dihydroxy-5-isopropylphenyl)-5-mercapto-4H-1,2,4-triazol-4-yl)-1H-indol-1-yl)ethyl)-4-(2,5-dioxopyrrolidin-1-yl)butanamide

Refernces

• 1、 Chandrasekhar,Padmaja,Raza. "Solid phase-solid state synthesis of N-alkyl imides from anhydrides". . p. 1597 - 1599. Retrieved 2007/10/03.
• 2、 Misra,Prakash. "Potential anticonvulsant drugs: Part II. Synthesis of succinimido/phthalimido butyryl ureas and thioureas". . p. 969 - 970. Retrieved 2007/10/08.