Nicotinamide, N,N-dipropyl-

Base Information

• Chemical Name: Nicotinamide, N,N-dipropyl-
• CAS No.: 10052-09-2
• Molecular Formula: C12H18 N2 O
• Molecular Weight: 206.28
• Hs Code.: 2933399090
• European Community (EC) Number: 654-370-9
• NSC Number: 165631
• DSSTox Substance ID: DTXSID20143362
• Nikkaji Number: J2.650.338H
• Wikidata: Q83007191
• Mol file: 10052-09-2.mol

Synonyms:N,N-dipropylpyridine-3-carboxamide;10052-09-2;Nicotinamide, N,N-dipropyl-;N,N-DIPROPYLNICOTINAMIDE;NSC165631;N,N-dipropyl-nicotinamide;Nicotinamide,N,N-dipropyl-;Nicotinamide, N,N-dipropyl-,;DTXSID20143362;AKOS003607579;NSC 165631;NSC-165631

Chemical Property of Nicotinamide, N,N-dipropyl-

Chemical Property:

• Vapor Pressure: 9.65E-05mmHg at 25°C
• Boiling Point: 338.7°Cat760mmHg
• Flash Point: 158.6°C
• PSA: 33.20000
• Density: 1.011g/cm³
• LogP: 2.34380
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 206.141913202
• Heavy Atom Count: 15
• Complexity: 188

Purity/Quality:

98%,99%, ^*data from raw suppliers

N,N-DIPROPYLNICOTINAMIDE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCN(CCC)C(=O)C1=CN=CC=C1

Technology Process of Nicotinamide, N,N-dipropyl-

There total 3 articles about Nicotinamide, N,N-dipropyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

pyridine-3-carbonitrile (100-54-9,121697-66-3,1232169-17-3,68271-95-4) + di-n-propylamine (142-84-7) → N,N-dipropylnicotinamide (10052-09-2)

Guidance literature:

di-n-propylamine; With ethylmagnesium bromide; In tetrahydrofuran; diethyl ether; at 30 ℃; for 1h;

pyridine-3-carbonitrile; In tetrahydrofuran; diethyl ether; at 30 ℃; for 1h;

With hydrogenchloride; In tetrahydrofuran; diethyl ether; dichloromethane; at 22 ℃;

DOI:10.1016/j.tetlet.2005.11.063

Reference yield:

nicotinic acid (59-67-6) + di-n-propylamine (142-84-7) → N,N-dipropylnicotinamide (10052-09-2)

Guidance literature:

With phosphorus pentoxide;

Reference yield:

→ N,N-dipropylnicotinamide (10052-09-2)

Guidance literature:

/BRN= 5743/;

upstream raw materials:

nicotinic acid

di-n-propylamine

pyridine-3-carbonitrile

Refernces