Benzoic acid, 2-(1-cyclohexen-1-ylmethyl)-2-(trichloroacetyl)hydrazide

Base Information

• Chemical Name: Benzoic acid, 2-(1-cyclohexen-1-ylmethyl)-2-(trichloroacetyl)hydrazide
• CAS No.: 651311-40-9
• Molecular Formula: C16H17Cl3N2O2
• Molecular Weight: 375.682
• Mol file: 651311-40-9.mol

Synonyms:

Chemical Property of Benzoic acid, 2-(1-cyclohexen-1-ylmethyl)-2-(trichloroacetyl)hydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzoic acid, 2-(1-cyclohexen-1-ylmethyl)-2-(trichloroacetyl)hydrazide

There total 2 articles about Benzoic acid, 2-(1-cyclohexen-1-ylmethyl)-2-(trichloroacetyl)hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-cyclohexene-1-carboxaldehyde (1192-88-7) → N'-(1-cyclohexenylmethyl)-N'-trichloroacetylbenzohydrazide (651311-40-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: CH₂Cl₂ / 20 °C

2.1: DMAB; methanesulfonic acid / diethyl ether / 3 h / 0 °C

2.2: 81 percent / pyridine / CH₂Cl₂ / 0 °C

With methanesulfonic acid; In diethyl ether; dichloromethane;

DOI:10.1016/j.tet.2003.10.046

Reference yield:

benzoic acid hydrazide (613-94-5) → N'-(1-cyclohexenylmethyl)-N'-trichloroacetylbenzohydrazide (651311-40-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: CH₂Cl₂ / 20 °C

2.1: DMAB; methanesulfonic acid / diethyl ether / 3 h / 0 °C

2.2: 81 percent / pyridine / CH₂Cl₂ / 0 °C

With methanesulfonic acid; In diethyl ether; dichloromethane;

DOI:10.1016/j.tet.2003.10.046

Reference yield: 77.0%

N'-(1-cyclohexenylmethyl)-N'-trichloroacetylbenzohydrazide (651311-40-9) → (+/-)-(5R,6S)-2-(benzoylamino)-4,4,6-trichloro-3-oxo-2-azaspiro[4.5]decane

Guidance literature:

With N,N,N,N,-tetramethylethylenediamine; copper(l) chloride; In acetonitrile; at 60 ℃; for 20h;

DOI:10.1016/j.tet.2003.10.046

upstream raw materials:

1-cyclohexene-1-carboxaldehyde

benzoic acid hydrazide

Downstream raw materials:

gabapentin-lactam

Refernces