3-(4-NITROPHENYL)PROPANOIC ACID

Base Information

• Chemical Name: 3-(4-NITROPHENYL)PROPANOIC ACID
• CAS No.: 10572-16-4
• Molecular Formula: C9H9NO5
• Molecular Weight: 211.174
• Hs Code.: 2918990090
• Mol file: 10572-16-4.mol

Synonyms:Propionicacid, 3-(p-nitrophenoxy)- (6CI,7CI,8CI);3-(4-Nitrophenoxy)propionic acid;3-(p-Nitrophenoxy)propionic acid;NSC 522110;

Chemical Property of 3-(4-NITROPHENYL)PROPANOIC ACID

Chemical Property:

• Vapor Pressure: 1.43E-06mmHg at 25°C
• Melting Point: 118-119 °C
• Boiling Point: 383.627 °C at 760 mmHg
• PKA: 4.00±0.10(Predicted)
• Flash Point: 185.811 °C
• PSA: 92.35000
• Density: 1.381 g/cm³
• LogP: 1.97150
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99.9% ^*data from raw suppliers

3-(4-Nitrophenoxy)propionicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(4-NITROPHENYL)PROPANOIC ACID

There total 6 articles about 3-(4-NITROPHENYL)PROPANOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

3-(4-nitrophenoxy)propanenitrile (69333-42-2) → 3-(4-nitrophenoxy)propanoic acid (10572-16-4)

Guidance literature:

With hydrogenchloride; In water; for 2h; Reflux;

DOI:10.1080/00397911.2016.1155714

Reference yield: 40.0%

3-Bromopropionic acid (590-92-1) + 4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) → 3-(4-nitrophenoxy)propanoic acid (10572-16-4)

Guidance literature:

With potassium hydroxide; In water; for 5h; Reflux;

Reference yield: 38.6%

chloropropionic acid (107-94-8) + 4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) → 3-(4-nitrophenoxy)propanoic acid (10572-16-4)

Guidance literature:

With potassium hydroxide; In ethanol; water; for 6h; Reflux;

upstream raw materials:

chloropropionic acid

4-nitro-phenol

β-Propiolactone

4-(4-nitrophenoxy)butanoic acid

Downstream raw materials:

3-[3-(4-nitrophenoxy)propionylamino]-5-methyl-2-hexanone

3-(4-Nitro-phenoxy)-N-(2-oxo-1-phenyl-propyl)-propionamide

α-<<3-(4-nitrophenoxy)propionyl>amino>propiophenone

N-(1-Cyclohexyl-2-oxo-propyl)-3-(4-nitro-phenoxy)-propionamide

Refernces

• 1、 Iida, Hirokazu,Akatsu, Yusuke,Mizukami, Kazushi,Natori, Sho,Matsukawa, Minako,Takahashi, Kie. "Efficient and rapid synthesis of phenolic analogs of 4-phenylbutanoic acid using microwave-assisted Michael addition as a key reaction". . p. 581 - 585. Retrieved 2016.