methyl 2,6-difluoro-3,5-dimethoxybenzoate

Base Information

• Chemical Name: methyl 2,6-difluoro-3,5-dimethoxybenzoate
• CAS No.: 651734-55-3
• Molecular Formula: C10H10F2O4
• Molecular Weight: 232.184
• Mol file: 651734-55-3.mol

Synonyms:Benzoic acid,2,6-difluoro-3,5-dimethoxy-,methyl ester;2,6-difluoro-3,5-dimethoxy benzoic acid methyl ester;

Chemical Property of methyl 2,6-difluoro-3,5-dimethoxybenzoate

Chemical Property:

• Boiling Point: 311.1±42.0 °C(Predicted)
• PSA: 44.76000
• Density: 1.263±0.06 g/cm3(Predicted)
• LogP: 1.76860
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

Methyl2,6-difluoro-3,5-dimethoxybenzoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 2,6-difluoro-3,5-dimethoxybenzoate

There total 3 articles about methyl 2,6-difluoro-3,5-dimethoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.6%

methyl 3,5-dimethoxybenzoate (2150-37-0) → methyl 2,6-difluoro-3,5-dimethoxybenzoate (651734-55-3)

Guidance literature:

With Selectfluor; In acetonitrile; at 20 ℃; Inert atmosphere;

Reference yield:

methyl 3,5-dimethoxybenzoate (2150-37-0) → methyl 2,6-difluoro-3,5-dimethoxybenzoate (651734-55-3) + methyl 2-fluoro-3,5-dimethoxybenzoate (651734-58-6)

Guidance literature:

With Selectfluor; In acetonitrile; at 0 - 20 ℃;

Reference yield:

methanol (67-56-1) + 2,6-difluoro-3,5-dimethoxybenzoic acid (651734-56-4) → methyl 2,6-difluoro-3,5-dimethoxybenzoate (651734-55-3)

Guidance literature:

2,6-difluoro-3,5-dimethoxybenzoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 25 ℃; for 1h; Inert atmosphere;

methanol; In dichloromethane; Inert atmosphere;

upstream raw materials:

methyl 3,5-dimethoxybenzoate

methanol

2,6-difluoro-3,5-dimethoxybenzoic acid

Downstream raw materials:

5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]-N-[4-(4-methylpiperazin-1-yl)phenyl]pyrimidin-2-amine

2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)-1H-pyrazol-1-yl]ethanol

5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]-N-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidin-2-amine

Refernces

• 1、 -. "HETEROCYCLICS AS INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR". Page/Page column 86. . Retrieved 2019/06/05.
• 2、 -. "FGFR4 INHIBITORS". Page/Page column 43. . Retrieved 2016/10/31.