4-Morpholinobenzaldehyde

Base Information

• Chemical Name: 4-Morpholinobenzaldehyde
• CAS No.: 1204-86-0
• Molecular Formula: C11H13 N O2
• Molecular Weight: 191.23
• Hs Code.: 29349990
• NSC Number: 156543
• DSSTox Substance ID: DTXSID30303076
• Nikkaji Number: J503.216D
• Wikidata: Q72492926
• ChEMBL ID: CHEMBL1874107
• Mol file: 1204-86-0.mol

Synonyms:4-Morpholinobenzaldehyde;1204-86-0;4-Morpholin-4-yl-benzaldehyde;4-(4-Formylphenyl)morpholine;4-(4-Morpholinyl)benzaldehyde;4-morpholin-4-ylbenzaldehyde;4-(morpholin-4-yl)benzaldehyde;4-morpholinobenzenecarbaldehyde;Benzaldehyde, 4-(4-morpholinyl)-;MFCD00735826;N-(4-formylphenyl)morpholine;NSC156543;4-morpholinylbenzaldehyde;Oprea1_040408;Oprea1_564273;p-(4-morpholinyl)benzaldehyde;SCHEMBL211336;SODIUMCYCLOHEXANEBUTYRATE;CHEMBL1874107;FOAQOAXQMISINY-UHFFFAOYSA-;DTXSID30303076;STK328566;4-(4-Morpholinyl)benzaldehyde, 97%;AKOS000113013;AC-2820;CS-W005097;NSC 156543;NSC-156543;NCGC00188273-01;NCGC00188273-02;SY003051;AM20060875;FT-0619152;M1625;EN300-01026;AB01334599-02;A804522;12Z-0700;J-004352;J-515842;4-morpholinobenzaldehyde;Z56922146;F1274-0239

Chemical Property of 4-Morpholinobenzaldehyde

Chemical Property:

• Vapor Pressure: 1.56E-05mmHg at 25°C
• Melting Point: 65-69 ºC
• Boiling Point: 365.5°Cat760mmHg
• PKA: 1.87±0.40(Predicted)
• Flash Point: 174.9°C
• PSA: 29.54000
• Density: 1.163g/cm³
• LogP: 1.40070
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: soluble in Methanol
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 191.094628657
• Heavy Atom Count: 14
• Complexity: 182

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Morpholin-4-yl-benzaldehyde ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1COCCN1C2=CC=C(C=C2)C=O

Technology Process of 4-Morpholinobenzaldehyde

There total 18 articles about 4-Morpholinobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

morpholine (110-91-8,99108-56-2) + 4-fluorobenzaldehyde (459-57-4) → 4-(4-morpholinyl)benzaldehyde (1204-86-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 130 ℃; for 12h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.5b01979

Reference yield: 99.0%

morpholine (110-91-8,99108-56-2) + 4-chlorobenzaldehyde (104-88-1) → 4-(4-morpholinyl)benzaldehyde (1204-86-0)

Guidance literature:

With ⁽⁵⁵⁾Pd₀₆₈⁽⁴⁴⁾Ni₀₃₂; potassium carbonate; In water; at 80 ℃; for 8h; Catalytic behavior;

DOI:10.1039/c4ra06958g

Reference yield: 99.0%

morpholine (110-91-8,99108-56-2) + 4-bromo-benzaldehyde (1122-91-4) → 4-(4-morpholinyl)benzaldehyde (1204-86-0)

Guidance literature:

With bis(η3-allyl-μ-chloropalladium(II)); [(μ-Ph2PCH2PPh2)Co2(CO)4(μ,η-Me2NCH2CCP(C6H11)2)]; sodium t-butanolate; In toluene; at 80 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.jorganchem.2008.12.046

upstream raw materials:

4-(bis(2-chloroethyl)amino)benzaldehyde

4-Phenylmorpholine

N,N-dimethyl-formamide

morpholine

Downstream raw materials:

1-(4-morpholino-trans-styryl)-isoquinoline

3-[4-(4-Morpholino)phenyl]-1-(9,10-dihydro-9,10-ethanoanthracen-2-yl)-2-propen-1-one

Refernces

• 1、 Can, Nafiz ?ncü,Osmaniye, Derya,Levent, Serkan,Sa?l?k, Begüm Nurpelin,Korkut, Bü?ra,Atl?, ?zlem,?zkay, Yusuf,Kaplanc?kl?, Zafer As?m. "Design, synthesis and biological assessment of new thiazolylhydrazine derivatives as selective and reversible hMAO-A inhibitors". . p. 68 - 81. Retrieved 2018.
• 2、 Qiu, Han-Yue,Wang, Peng-Fei,Li, Zhen,Ma, Jun-Ting,Wang, Xiao-Ming,Yang, Yong-Hua,Zhu, Hai-Liang. "Synthesis of dihydropyrazole sulphonamide derivatives that act as anti-cancer agents through COX-2 inhibition". . p. 86 - 96. Retrieved 2016.
• 3、 Emam, Soha H.,Sonousi, Amr,Osman, Eman O.,Hwang, Dukhyun,Kim, Gun-Do,Hassan, Rasha A.. "Design and synthesis of methoxyphenyl- and coumarin-based chalcone derivatives as anti-inflammatory agents by inhibition of NO production and down-regulation of NF-κB in LPS-induced RAW264.7 macrophage cells". . . Retrieved 2021/01/20.
• 4、 Cao, Zhongcheng,Deng, Yong,Li, Wei,Shi, Yichun,Song, Qing,Yang, Xia,Zhang, Li. "Pyridoxine-resveratrol hybrids as novel inhibitors of MAO-B with antioxidant and neuroprotective activities for the treatment of Parkinson's disease". . . Retrieved 2020/03/10.