3-Pyridinesulfonic acid, hydrazide

Base Information

• Chemical Name: 3-Pyridinesulfonic acid, hydrazide
• CAS No.: 65227-53-4
• Molecular Formula: C5H7N3O2S
• Molecular Weight: 173.195
• Mol file: 65227-53-4.mol

Synonyms:

Chemical Property of 3-Pyridinesulfonic acid, hydrazide

Chemical Property:

• PSA: 93.46000
• LogP: 1.40560

Purity/Quality:

97% ^*data from raw suppliers

Pyridine-3-sulfonohydrazide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Pyridinesulfonic acid, hydrazide

There total 3 articles about 3-Pyridinesulfonic acid, hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

pyridine-3-sulfonyl chloride hydrochloride (42899-76-3) → pyridine-3-sulfonohydrazide (65227-53-4)

Guidance literature:

With hydrazine hydrate; In methanol; at 10 ℃; for 1h;

Reference yield: 35.0%

Pyridine-3-sulfonyl chloride (16133-25-8) → pyridine-3-sulfonohydrazide (65227-53-4)

Guidance literature:

With hydrazine hydrate; In tetrahydrofuran; at -15 ℃; for 0.5h;

DOI:10.1002/ardp.201400082

Reference yield:

3-pyridinesulfonic acid (636-73-7) → pyridine-3-sulfonohydrazide (65227-53-4)

Guidance literature:

Multi-step reaction with 2 steps

1: PCl₅

2: 69 percent / N₂H₄*H₂O / methanol / 1 h / 10 °C

With phosphorus pentachloride; hydrazine hydrate; In methanol;

upstream raw materials:

Pyridine-3-sulfonyl chloride

pyridine-3-sulfonyl chloride hydrochloride

3-pyridinesulfonic acid

Downstream raw materials:

pyridine-3-sulfinic acid

3-Benzoylpyridine

2-pyridin-3-yl-quinoline

3-(benzylsulfonyl)pyridine

Refernces

• 1、 Deng, Lei,Kleij, Arjan W.,Yang, Weibo. "Diversity-Orientated Stereoselective Synthesis through Pd-Catalyzed Switchable Decarboxylative C?N/C?S Bond Formation in Allylic Surrogates". supporting information. p. 19156 - 19161. Retrieved 2018/11/30.
• 2、 Cremlyn, Richard J.,Jones, Graham P.,Swinbourne, Fred J.,Yung, Kin. "SOME REACTIONS OF PYRIDINE-3-SULFONYL CHLORIDE". . p. 189 - 196. Retrieved 2007/10/02.