Methyl pyrimidine-5-carboxylate

Base Information

• Chemical Name: Methyl pyrimidine-5-carboxylate
• CAS No.: 34253-01-5
• Molecular Formula: C6H6N2O2
• Molecular Weight: 138.126
• Hs Code.: 2933599090
• Mol file: 34253-01-5.mol

Synonyms:5-Pyrimidicarboxylic acid methyl ester;Methyl 5-pyrimidinecarboxylate;

Chemical Property of Methyl pyrimidine-5-carboxylate

Chemical Property:

• Vapor Pressure: 0.092mmHg at 25°C
• Melting Point: 76-81°C
• Refractive Index: 1.513
• Boiling Point: 224.3 °C at 760 mmHg
• PKA: 1.13±0.10(Predicted)
• Flash Point: 89.4 °C
• PSA: 52.08000
• Density: 1.213 g/cm³
• LogP: 0.26320
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl pyrimidine-5-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of Methyl pyrimidine-5-carboxylate

There total 5 articles about Methyl pyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

5-bromopyrimidine (4595-59-9) + propan-1-ol (71-23-8) → pyrimidine-5-carboxylic acid methyl ester (34253-01-5) + 3-pyrimidinecarboxylic acid methyl ester

Guidance literature:

With tributyl-amine; bis(triphenylphosphine)palladium(II)-chloride; In N,N-dimethyl-formamide;

Reference yield: 44.0%

5-bromopyrimidine (4595-59-9) + methanol (67-56-1) + carbon monoxide (201230-82-2) → pyrimidine-5-carboxylic acid methyl ester (34253-01-5)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; triethylamine; In N,N-dimethyl-formamide; at 90 ℃; under 760 Torr;

DOI:10.1016/S0960-894X(00)00318-8

Reference yield:

pyrimidine-5-carboxylic acid (4595-61-3) → pyrimidine-5-carboxylic acid methyl ester (34253-01-5)

Guidance literature:

With potassium hydroxide; acetic acid; In tetrahydrofuran; ethanol; water;

upstream raw materials:

5-bromopyrimidine

methanol

carbon monoxide

palladium diacetate

Downstream raw materials:

methyl 2-isopropylpyrimidine-5-carboxylate

pyrimidine-5-carboxylic acid

pyrimidine-5-carbohydrazide

pyrimidine-5-carboxamide

Refernces

• 1、 -. "Inhibitors of protein isoprenyl transferases". . . Retrieved 2008/06/13.
• 2、 -. "Muscarinic agonists". . . Retrieved 2008/06/13.