TRITYL ISOTHIOCYANATE

Base Information

• Chemical Name: TRITYL ISOTHIOCYANATE
• CAS No.: 1726-94-9
• Molecular Formula: C20H15NS
• Molecular Weight: 301.412
• Hs Code.: 2930909090
• Mol file: 1726-94-9.mol

Synonyms:Trityl isothiocyanate;Triphenylmethyl isothiocyanate;isothiocyanatotriphenylmethane;

Chemical Property of TRITYL ISOTHIOCYANATE

Chemical Property:

• Vapor Pressure: 1.41E-06mmHg at 25°C
• Melting Point: 136-140 °C(lit.)
• Refractive Index: 1.596
• Boiling Point: 410.7 °C at 760 mmHg
• Flash Point: 217 °C
• PSA: 44.45000
• Density: 1.04 g/cm³
• LogP: 5.08130
• Storage Temp.: 2-8°C
• Sensitive.: Moisture Sensitive

Purity/Quality:

99% ^*data from raw suppliers

Trityl isothiocyanate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38-42
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of TRITYL ISOTHIOCYANATE

There total 21 articles about TRITYL ISOTHIOCYANATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.5%

3,4,6-tri-O-acetyl-2-O-methyl-β-D-glucopyranosyl thiocyanate (127066-71-1) + 1,2,3,6-tetra-O-acetyl-4-O-trityl-β-D-glucopyranose (99337-73-2) → trityl isothiocyanate (1726-94-9) + 1,2,3,6-tetra-O-acetyl-4-O-(3,4,6-tri-O-acetyl-2-O-methyl-α-D-glucopyranosyl)-β-D-glucopyranose (127088-73-7)

Guidance literature:

triphenylmethyl perchlorate; In dichloromethane; for 2h; Ambient temperature;

DOI:10.1016/S0040-4039(01)80593-1

Reference yield: 81.0%

triphenylmethyl alcohol (76-84-6) + sodium thiocyanide (540-72-7) → trityl isothiocyanate (1726-94-9)

Guidance literature:

With oxalic acid; In nitromethane; at 60 ℃; for 6h;

DOI:10.1246/cl.2006.1262

Reference yield: 77.5%

methyl 2,3,4-tri-O-acetyl-6-O-trityl-α-D-glucopyranoside (7511-40-2,18031-49-7,31873-39-9,38982-56-8,63167-74-8,87591-35-3) + 3,4,6-tri-O-acetyl-2-O-methyl-β-D-glucopyranosyl thiocyanate (127066-71-1) → trityl isothiocyanate (1726-94-9) + methyl 2,3,4-tri-O-acetyl-6-O-(3,4,6-tri-O-acetyl-2-O-methyl-α-D-glucopyranosyl)-α-D-glucopyranoside (127066-73-3)

Guidance literature:

triphenylmethyl perchlorate; In dichloromethane; for 2h; Ambient temperature;

DOI:10.1016/S0040-4039(01)80593-1

upstream raw materials:

thiocyanatochloride

triphenylmethane

thiocyanogen

methyl 2,3,4-tri-O-acetyl-6-O-trityl-α-D-glucopyranoside

Downstream raw materials:

trityl thioacetic acid

N,N-dimethyl-N′-(tritylcarbamothioyl)formimidamide

N,N-diethyl-N′-(tritylcarbamothioyl)acetimidamide

(S)-1-(1-(diphenylphosphino)-3-methylbutan-2-yl)-3-tritylthiourea

Refernces

• 1、 -. "Synthesis methods for isothiocyanate derivative". Paragraph 0033; 0034; 0035; 0036; 0113; 0114; 0115; 0116. . Retrieved 2019/05/22.
• 2、 Khajeh-Kolaki, Aslan,Mokhtari, Babak. "2,4,4,6-Tetrabromo-2,5-cyclohexadienone as an efficient reagent for phosphine-free electrophilic transformation of alcohols and epoxides". . p. 251 - 258. Retrieved 2016/06/01.