1-(3-BROMOPROPOXY)-4-METHYLBENZENE

Base Information

• Chemical Name: 1-(3-BROMOPROPOXY)-4-METHYLBENZENE
• CAS No.: 16929-24-1
• Molecular Formula: C10H13 Br O
• Molecular Weight: 229.117
• Hs Code.: 2909309090
• Mol file: 16929-24-1.mol

Synonyms:Ether,3-bromopropyl p-tolyl (8CI); 3-(p-Tolyloxy)propyl bromide

Chemical Property of 1-(3-BROMOPROPOXY)-4-METHYLBENZENE

Chemical Property:

• Vapor Pressure: 0.00375mmHg at 25°C
• Refractive Index: 1.539-1.541
• Boiling Point: 135-145 °C (14 mmHg)
• Flash Point: 114.6°C
• PSA: 9.23000
• Density: 1.302g/cm³
• LogP: 3.15880

Purity/Quality:

98.5% ^*data from raw suppliers

1-(3-Bromopropoxy)-4-methylbenzene 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 36/37/38-20/22
• Safety Statements: 37/39-26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(3-BROMOPROPOXY)-4-METHYLBENZENE

There total 6 articles about 1-(3-BROMOPROPOXY)-4-METHYLBENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

allyl p-tolyl ether (23431-48-3) → 1-(3-bromopropoxy)-4-methylbenzene (16929-24-1)

Guidance literature:

With sulfuric acid; sodium bromide; dibenzoyl peroxide; In tetrachloromethane; at 60 ℃; for 2h;

Reference yield: 92.3%

p-cresol (106-44-5) + 1,3-dibromo-propane (109-64-8) → 1-(3-bromopropoxy)-4-methylbenzene (16929-24-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

DOI:10.1016/j.ejmech.2009.05.018

Reference yield:

p-cresol (106-44-5) + 1.3-chlorobromopropane (109-70-6) → 1-(3-bromopropoxy)-4-methylbenzene (16929-24-1) + (3-chloro-propyl)-p-tolyl ether (79096-53-0)

Guidance literature:

With sodium hydroxide; tetrabutylammomium bromide; In toluene; for 24h; Yield given. Yields of byproduct given; Heating;

DOI:10.1055/s-1990-27096

upstream raw materials:

p-cresol

1,3-dibromo-propane

3-(4-methylphenoxy)propan-1-ol

1.3-chlorobromopropane

Downstream raw materials:

N-ethyl-N-[1-[3-(4-methylphenoxy)propyl]-4-piperidinyl]-2-benzothiazolamine

8-fluoro-5-(3-(p-tolyloxy)propyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

C₂₄H₂₇FN₂O₃

(E)-ethyl 3-{5-{{benzyl[3-(p-tolyloxy)propyl]amino}methyl}furan-2-yl}acrylate

Refernces

• 1、 -. "ORGANIC COMPOUNDS". Paragraph 00182. . Retrieved 2020/07/14.
• 2、 Tu, Jie,Li, Zhuang,Jiang, Yanjuan,Ji, Changjin,Han, Guiyan,Wang, Yan,Liu, Na,Sheng, Chunquan. "Discovery of Carboline Derivatives as Potent Antifungal Agents for the Treatment of Cryptococcal Meningitis". . p. 2376 - 2389. Retrieved 2019/03/07.