Tris[2-(methylamino)ethyl]amine

Base Information

• Chemical Name: Tris[2-(methylamino)ethyl]amine
• CAS No.: 65604-89-9
• Molecular Formula: C9H24N4
• Molecular Weight: 188.316
• Hs Code.: 2921290000
• European Community (EC) Number: 625-935-7
• DSSTox Substance ID: DTXSID30447207
• Nikkaji Number: J1.007.694C
• Wikidata: Q82266034
• Mol file: 65604-89-9.mol

Synonyms:Tris[2-(methylamino)ethyl]amine;65604-89-9;N-methyl-N',N'-bis[2-(methylamino)ethyl]ethane-1,2-diamine;tris(2-(methylamino)ethyl)amine;Tris[2-(methylamino)ethyl]amine, 97%;TRIS(2-(METHYLAMINO)ETHYL)AMINE, 97%;1,2-Ethanediamine, N'-methyl-N,N-bis[2-(methylamino)ethyl]-;SCHEMBL562717;DTXSID30447207;CS-0204379;(2-{BIS[2-(METHYLAMINO)ETHYL]AMINO}ETHYL)(METHYL)AMINE

Chemical Property of Tris[2-(methylamino)ethyl]amine

Chemical Property:

• Boiling Point: 77-78oC/0.1 mmHg(lit.)
• PKA: 10.56±0.10(Predicted)
• Flash Point: 109oC
• PSA: 39.33000
• Density: 0.896 g/mL at 25oC(lit.)
• LogP: 0.11930
• XLogP3: -1
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 9
• Exact Mass: 188.20009678
• Heavy Atom Count: 13
• Complexity: 78.6

Purity/Quality:

98%,99%, ^*data from raw suppliers

Tris[2-(methylamino)ethyl]amine 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CNCCN(CCNC)CCNC

Technology Process of Tris[2-(methylamino)ethyl]amine

There total 14 articles about Tris[2-(methylamino)ethyl]amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

tris-(2-N-benzyl-N-methylaminoethyl)amine → tris[2-(methylamino)ethyl]amine (65604-89-9)

Guidance literature:

With hydrogen; palladium dihydroxide; In methanol; at 60 ℃; for 20h;

DOI:10.1039/a707785h

Reference yield: 80.0%

2,2',2''-triaminotriethylamine (4097-89-6) + chloroformic acid ethyl ester (541-41-3) → tris[2-(methylamino)ethyl]amine (65604-89-9)

Guidance literature:

2,2',2''-triaminotriethylamine; chloroformic acid ethyl ester; In water; toluene;

With lithium aluminium tetrahydride; In tetrahydrofuran; water; toluene;

DOI:10.1002/chem.200600964

Reference yield: 56.0%

tris(N-ethoxycarbonyl-2-aminoethyl)amine (127787-96-6) → tris[2-(methylamino)ethyl]amine (65604-89-9)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1002/1521-3765(20020703)8:13<2988::AID-CHEM2988>3.0.CO;2-2

upstream raw materials:

tris(N-ethoxycarbonyl-2-aminoethyl)amine

2,2',2''-triaminotriethylamine

chloroformic acid ethyl ester

1-methyl-N,N',N''-trimethylazagermatrane

Downstream raw materials:

proazaphosphatrane

tris(4-phenylphosphinato-3-methyl-3-azabutyl)amine trihydrochloride monohydrate

4,4',4''-{nitrilotris[2,1-ethanediyl(methylimino)methylene]}tris(2-methoxymethoxy)-benzoic acid trimethyl ester

4,4',4''-{nitrilotris[2,1-ethanediyl(methylimino)methylene]}tris(2-methoxymethoxy-N-aminoethyl)-benzamide

Refernces

• 1、 Geraldes, Carlos F. G. C.,Bruecher, Erno,Cortes, Sergio,Koenig, Seymour H.,Sherry, A. Dean. "Synthesis and Complexation Properties of a New Tetraazatricarboxylate Ligand". . p. 2517 - 2522. Retrieved 1992.
• 2、 Li, Chunyang,Manick, Anne-Doriane,Yang, Jian,Givaudan, David,Biletskyi, Bohdan,Michaud-Chevalier, Sabine,Dutasta, Jean-Pierre,Hérault, Damien,Bugaut, Xavier,Chatelet, Bastien,Martinez, Alexandre. "The Chloroazaphosphatrane Motif for Halogen Bonding in Solution". supporting information. p. 11964 - 11973. Retrieved 2021/08/20.
• 3、 Chatelet, Bastien,Joucla, Lionel,Dutasta, Jean-Pierre,Martinez, Alexandre,Szeto, Kai C.,Dufaud, Veronique. "Azaphosphatranes as structurally tunable organocatalysts for carbonate synthesis from CO2 and epoxides". supporting information. p. 5348 - 5351. Retrieved 2013/06/05.