amino(phenyl)propanedioic acid

Base Information

• Chemical Name: amino(phenyl)propanedioic acid
• CAS No.: 51619-79-5
• Molecular Formula: C9H9NO4
• Molecular Weight: 195.175
• Mol file: 51619-79-5.mol

Synonyms:

Chemical Property of amino(phenyl)propanedioic acid

Chemical Property:

• Vapor Pressure: 1.36E-06mmHg at 25°C
• Boiling Point: 384.3°Cat760mmHg
• Flash Point: 186.2°C
• Density: 1.472g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of amino(phenyl)propanedioic acid

There total 2 articles about amino(phenyl)propanedioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

α-Amino-α-phenyl-malonsaeure-diaethylester (22225-53-2) → 2-amino-2-phenyl malonic acid (51619-79-5)

Guidance literature:

With sodium hydroxide; In ethanol; water; for 3h; Reflux;

DOI:10.1002/anie.200904112

Reference yield:

→ 2-amino-2-phenyl malonic acid (51619-79-5)

Guidance literature:

Diethyl-α-phenylaminomalonat, KOH;

DOI:10.1021/bi00749a014

Reference yield:

2-amino-2-phenyl malonic acid (51619-79-5) → (R)-phenylglycine (875-74-1) + phenylglycin (2835-06-5)

Guidance literature:

With recombinant Bordetella bronchiseptica arylmalonate decarboxylase from E_. coli BL₂₁ (DE₃); optical yield given as %ee; Enzymatic reaction;

DOI:10.1002/anie.200904112

upstream raw materials:

α-Amino-α-phenyl-malonsaeure-diaethylester

Downstream raw materials:

(R)-phenylglycine

phenylglycin

Refernces

• 1、 Okrasa, Krzysztof,Wilding, Matthew,Goodall, Mark,Micklefield, Jason,Levy, Colin,Leys, David,Baudendistel, Nina,Hauer, Bernhard. "Structure-guided directed evolution of alkenyl and arylmalonate decarboxylases". supporting information; experimental part. p. 7691 - 7694. Retrieved 2009/12/31.