2-(Trichloroacetyl)pyrrole

Base Information

• Chemical Name: 2-(Trichloroacetyl)pyrrole
• CAS No.: 35302-72-8
• Molecular Formula: C6H4Cl3NO
• Molecular Weight: 212.463
• Hs Code.: 29339900
• Mol file: 35302-72-8.mol

Synonyms:2,2,2-Trichloro-1-(1H-pyrrol-2-yl)ethanone;Ethanone,2,2,2-trichloro-1-(1H-pyrrol-2-yl)-;NSC 272669;Pyrrol-2-yl trichloromethyl ketone;

Chemical Property of 2-(Trichloroacetyl)pyrrole

Chemical Property:

• Vapor Pressure: 0.00282mmHg at 25°C
• Melting Point: 72-74 °C(lit.)
• Refractive Index: 1.592
• Boiling Point: 285.3 °C at 760mmHg
• PKA: 14.18±0.50(Predicted)
• Flash Point: 126.364 °C
• PSA: 32.86000
• Density: 1.591 g/cm³
• LogP: 2.56760
• Storage Temp.: 2-8°C
• Solubility.: Chloroform, Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(Trichloroacetyl)pyrrole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38-36/37//38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 2-(Trichloroacetyl)pyrrole, is a building block used for the synthesis of more complex pharmaceutical compounds, such as Oroidin, Hymenidin and Clathrodin.

Technology Process of 2-(Trichloroacetyl)pyrrole

There total 8 articles about 2-(Trichloroacetyl)pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

pyrrole (109-97-7,30604-81-0) + trifluoroacetyl chloride (76-02-8) → pyrrol-2-yl trichloromethyl ketone (35302-72-8)

Guidance literature:

In diethyl ether; at 0 ℃; for 48h;

DOI:10.3762/bjoc.11.101

Reference yield: 53.0%

pyrrole (109-97-7,30604-81-0) + 1,1,1-trichloroacetone (918-00-3,861255-82-5) → pyrrol-2-yl trichloromethyl ketone (35302-72-8)

Guidance literature:

DOI:10.1021/jo00009a008

Reference yield:

N-Methylpyrrole (96-54-8) + trifluoroacetyl chloride (76-02-8) → pyrrol-2-yl trichloromethyl ketone (35302-72-8)

Guidance literature:

With potassium carbonate; In diethyl ether; water;

upstream raw materials:

pyrrole

1,1,1-trichloroacetone

trifluoroacetyl chloride

trichloroacetic acid anhydride

Downstream raw materials:

2,2,2-trichloro-1-(4-nitro-1H-pyrrol-2-yl)ethan-1-one

1-[(5-chloro-2-nitrophenyl)sulfonyl]-2-trichloroacetyl-1H-pyrrole

lamellarin D

methyl 2-(2,4-diisopropoxy-5-methoxyphenyl)-8-isopropoxy-1-(4-isopropoxy-3-methoxyphenyl)-9-methoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-3-carboxylate

Refernces

• 1、 Keifer, Paul A.,Schwartz, Robert E.,Koker, Moustapha E. S.,Hughes, Robert G.,Rittschof, Dan,Rinehart, Kenneth L.. "Bioactive Bromopyrrole Metabolites from the Caribbean Sponge Agelas conifera". . p. 2965 - 2975. Retrieved 1991.
• 2、 -. "Synthetic method 3 - ethylamine-based pyrrole compound (by machine translation)". Paragraph 0021-0024. . Retrieved 2020/06/09.
• 3、 van Rensburg, Michelle,Copp, Brent R.,Barker, David. "Synthesis and Absolute Stereochemical Reassignment of Mukanadin F: A Study of Isomerization of Bromopyrrole Alkaloids with Implications on Marine Natural Product Isolation". . p. 3065 - 3074. Retrieved 2018/07/06.