2,4-dichloro-6-phenylpyrimidine

Base Information

• Chemical Name: 2,4-dichloro-6-phenylpyrimidine
• CAS No.: 26032-72-4
• Molecular Formula: C10H6Cl2N2
• Molecular Weight: 225.077
• Hs Code.: 2933599090
• Mol file: 26032-72-4.mol

Synonyms:NSC 49018;2,4-Dichloro-6-phenylpyrimidine;

Chemical Property of 2,4-dichloro-6-phenylpyrimidine

Chemical Property:

• Vapor Pressure: 4.39E-05mmHg at 25°C
• Melting Point: 92-93℃
• Refractive Index: 1.604
• Boiling Point: 361.2 °C at 760 mmHg
• PKA: -3.45±0.30(Predicted)
• Flash Point: 203.6 °C
• PSA: 25.78000
• Density: 1.363 g/cm³
• LogP: 3.45040
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99.0% ^*data from raw suppliers

2,4-Dichloro-6-phenylpyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-dichloro-6-phenylpyrimidine

There total 18 articles about 2,4-dichloro-6-phenylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2,4,6-trichloropyrimidine (3764-01-0) + phenylboronic acid (98-80-6) → 2,4-dichloro-6-phenyl-pyrimidine (26032-72-4)

Guidance literature:

With palladium diacetate; sodium carbonate; triphenylphosphine; In tetrahydrofuran; at 60 ℃; for 3h;

DOI:10.1021/ol052578p

Reference yield: 84.0%

6-phenyl-2,4,5-trichloro-1,6-dihydropyrimidine (86984-17-0) → 2,4-dichloro-6-phenyl-pyrimidine (26032-72-4)

Guidance literature:

With triethylamine; In toluene; for 5h; Heating;

Reference yield: 71.0%

2,6-Dichloropyrimidine (3934-20-1) + phenyllithium (591-51-5) → 2,4-dichloro-6-phenyl-pyrimidine (26032-72-4)

Guidance literature:

2,6-Dichloropyrimidine; phenyllithium; In tetrahydrofuran; at -70 - -30 ℃; for 3h;

With water; In tetrahydrofuran;

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; at 20 ℃; for 0.25h;

upstream raw materials:

6-phenyluracil

2,4-dichloro-5-fluoro-6-phenyl-1,6-dihydropyrimidine

6-phenyl-2,4,5-trichloro-1,6-dihydropyrimidine

4-phenyl-pyrimidine 1,3-dioxide

Downstream raw materials:

2-chloro-N-(4-chlorophenyl)-6-phenylpyrimidin-4-amine

N-(4-chlorophenyl)-4-phenyl-6-(2-(4-(trifluoromethoxy)benzylidene)hydrazinyl)pyrimidin-2-amine

(2-chloro-6-phenyl-pyrimidin-4-yl)-cyclobutyl-amine

(S)-2-(2-chloro-6-phenyl-pyrimidin-4-ylamino)-2-phenyl-ethanol

Refernces

• 1、 Vuorinen, Aini,Wilkinson, Isabel V.L.,Chatzopoulou, Maria,Edwards, Ben,Squire, Sarah E.,Fairclough, Rebecca J.,Bazan, Noelia Araujo,Milner, Josh A.,Conole, Daniel,Donald, James R.,Shah, Nandini,Willis, Nicky J.,Martínez, R. Fernando,Wilson, Francis X.,Wynne, Graham M.,Davies, Stephen G.,Davies, Kay E.,Russell, Angela J.. "Discovery and mechanism of action studies of 4,6-diphenylpyrimidine-2-carbohydrazides as utrophin modulators for the treatment of Duchenne muscular dystrophy". supporting information. . Retrieved 2021/05/03.
• 2、 -. "Anthracene derivatives and organic light-emitting diode including the same". Paragraph 0169; 0201-0206. . Retrieved 2019/10/22.