sulfinosine

Base Information

• Chemical Name: sulfinosine
• CAS No.: 124508-99-2
• Molecular Formula: C10H14 N6 O5 S
• Molecular Weight: 330.32
• Mol file: 124508-99-2.mol

Synonyms:Sulfinosine

Chemical Property of sulfinosine

Chemical Property:

• Vapor Pressure: 1.89E-34mmHg at 25°C
• Boiling Point: 895.3°Cat760mmHg
• PKA: 7.86±0.30(Predicted)
• Flash Point: 495.2°C
• PSA: 201.84000
• Density: 2.46g/cm³
• LogP: -0.85150

Purity/Quality:

98%Min ^*data from raw suppliers

SULFINOSINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of sulfinosine

There total 2 articles about sulfinosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

2-amino-9-β-D-ribofuranosylpurine-6-sulfenamide (123002-38-0) → 3-deazasulfinosine (124508-99-2)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In ethanol; at 0 - 5 ℃; for 0.25h;

DOI:10.1021/jm00166a021

Reference yield:

6-thioguanosine (85-31-4) → 3-deazasulfinosine (124508-99-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 73.7 percent / ClNH₂, 2 N KOH / 1.5 h / 0 °C

2: 67 percent / 85percent 3-chloroperoxybenzoic acid / ethanol / 0.25 h / 0 - 5 °C

With potassium hydroxide; chloroamine; 3-chloro-benzenecarboperoxoic acid; In ethanol;

DOI:10.1021/jm00166a021

upstream raw materials:

2-amino-9-β-D-ribofuranosylpurine-6-sulfenamide

6-thioguanosine

Refernces

• 1、 Ramasamy, Kandasamy,Imamura, Nobutaka,Hanna, Naeem B.,Finch, Rick A.,Avery, Thomas L.,et al.. "Synthesis and Antitumor Evaluation in Mice of Certain 7-Deazapurine (Pyrrolopyrimidine) and 3-Deazapurine (Imidazopyridine) Nucleosides Structurally Related to Sulfenosine, Sulfinosine, and Sulfonosine". . p. 1220 - 1225. Retrieved 2007/10/02.