N1-(4-BUTYLPHENYL)ACETAMIDE

Base Information

• Chemical Name: N1-(4-BUTYLPHENYL)ACETAMIDE
• CAS No.: 3663-20-5
• Molecular Formula: C12H17NO
• Molecular Weight: 191.273
• Hs Code.: 2924299090
• Mol file: 3663-20-5.mol

Synonyms:Acetanilide,4'-butyl- (7CI,8CI);4-(n-Butyl)acetanilide;4'-Butylacetanilide;N-(4-Butylphenyl)acetamide;p-Butylacetanilide;

Chemical Property of N1-(4-BUTYLPHENYL)ACETAMIDE

Chemical Property:

• Vapor Pressure: 4.65E-05mmHg at 25°C
• Melting Point: 107 °C
• Refractive Index: 1.542
• Boiling Point: 349.6 °C at 760 mmHg
• Flash Point: 208.8 °C
• PSA: 29.10000
• Density: 1.015 g/cm³
• LogP: 3.06060

Purity/Quality:

99.3% ^*data from raw suppliers

N-(4-Butylphenyl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R22:Harmful if swallowed.
• Hazard Codes: Xn:Harmful
• Statements: R22:Harmful if swallowed.

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N1-(4-BUTYLPHENYL)ACETAMIDE

There total 12 articles about N1-(4-BUTYLPHENYL)ACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(4-butylphenyl)acetylene (79887-09-5) → N-(4-butylphenyl)acetamide (3663-20-5)

Guidance literature:

With trimethylsilylazide; silver carbonate; trifluoroacetic acid; In water; 1,2-dichloro-ethane; at 60 ℃; for 12h; Schlenk technique; Inert atmosphere;

DOI:10.1002/adsc.201700783

Reference yield: 92.0%

4-Butylaniline (104-13-2) + acetic anhydride (108-24-7) → N-(4-butylphenyl)acetamide (3663-20-5)

Guidance literature:

With N,N,N-trimethyl-2-(sulfooxy)ethanaminium chloride; In neat (no solvent); at 20 ℃; for 0.233333h; Milling; Green chemistry;

DOI:10.1016/j.tetlet.2017.03.023

Reference yield: 90.3%

4-Butylaniline (104-13-2) → N-(4-butylphenyl)acetamide (3663-20-5)

Guidance literature:

With acetic anhydride; In ethanol; water; toluene;

upstream raw materials:

4-Butylaniline

acetic anhydride

acetic acid

1-butyl-4-nitro-benzene

Downstream raw materials:

5-n-butyl-1H-benzotriazole

6-butyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

4-Butylaniline

2-acetamido-5-butylphenyl 4-chlorobenzoate

Refernces

• 1、 Jiao, Ning,Liu, Jianzhong,Qiu, Xu,Song, Song,Wei, Jialiang,Wen, Xiaojin,Zhang, Cheng,Zhang, Ziyao. "Nitromethane as a nitrogen donor in Schmidt-type formation of amides and nitriles". supporting information. p. 281 - 285. Retrieved 2020/01/28.
• 2、 Kalla, Reddi Mohan Naidu,Lim, Jaehwa,Bae, Jaeyeong,Kim, Il. "Sulfated choline ionic liquid-catalyzed acetamide synthesis by grindstone method". supporting information. p. 1595 - 1599. Retrieved 2017/04/03.