Formamide, N-(3,5-dimethylphenyl)-N-methyl-

Base Information

• Chemical Name: Formamide, N-(3,5-dimethylphenyl)-N-methyl-
• CAS No.: 65772-54-5
• Molecular Formula: C10H13NO
• Molecular Weight: 163.219
• Mol file: 65772-54-5.mol

Synonyms:

Chemical Property of Formamide, N-(3,5-dimethylphenyl)-N-methyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Formamide, N-(3,5-dimethylphenyl)-N-methyl-

There total 9 articles about Formamide, N-(3,5-dimethylphenyl)-N-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

indole (120-72-9) + N-Methylformamide (123-39-7) + 3,5-dimethylphenyl iodide (22445-41-6) + bis(N-methylimidazol-2-yl)ketone (62366-40-9) → N-(3,5-dimethylphenyl)-N-methylformamide (65772-54-5)

Guidance literature:

With potassium phosphate; CuI; In dodecane; ethyl acetate; toluene;

Reference yield: 93.0%

N-Methylformamide (123-39-7) + 3,5-dimethylphenyl benzenesulfonate (61019-00-9) → N-(3,5-dimethylphenyl)-N-methylformamide (65772-54-5)

Guidance literature:

With palladium diacetate; XPhos; phenylboronic acid; potassium carbonate; In tert-butyl alcohol; at 110 ℃; for 20h;

DOI:10.1021/ja035483w

Reference yield: 75.0%

3,5,N,N-tetramethylaniline (4913-13-7) → N-(3,5-dimethylphenyl)-N-methylformamide (65772-54-5)

Guidance literature:

With air; In 1,2-dimethoxyethane; at 20 ℃; under 760.051 Torr; Irradiation;

DOI:10.1021/acs.orglett.7b01230

upstream raw materials:

N-(3,5-dimethylphenyl)formamide

dimethyl sulfate

N-Methylformamide

3,5-dimethylphenyl benzenesulfonate

Refernces

• 1、 Yang, Shuai,Li, Pinhua,Wang, Zhihui,Wang, Lei. "Photoinduced Oxidative Formylation of N,N-Dimethylanilines with Molecular Oxygen without External Photocatalyst". supporting information. p. 3386 - 3389. Retrieved 2017/07/15.
• 2、 Huang, Xiaohua,Anderson, Kevin W.,Zim, Danilo,Jiang, Lei,Klapars, Artis,Buchwald, Stephen L.. "Expanding Pd-catalyzed C-N bond-forming processes: The first amidation of aryl sulfonates, aqueous amination, and complementarity with Cu-catalyzed reactions". . p. 6653 - 6655. Retrieved 2007/10/03.